Effects of phosphodiesterase-5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: a randomized trial

被引：37

作者：

Dimitriadis, Fotios ^{[1
,2
]}

Tsambalas, Stavros ^{[2
]}

Tsounapi, Panagiota ^{[1
]}

Kawamura, Hiroshi ^{[2
]}

Vlachopoulou, Evlalia ^{[2
]}

Haliasos, Nikolaos ^{[2
]}

Gratsias, Stavros ^{[2
]}

Watanabe, Takeshi ^{[1
]}

Saito, Motoaki ^{[3
]}

Miyagawa, Ikuo ^{[1
]}

Sofikitis, Nikolaos ^{[1
,2
]}

机构：

[1] Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan

[2] Tottori Univ, Dept Pathophysiol & Therapeut Sci, Div Mol Pharmacol, Fac Med, Yonago, Tottori 6838503, Japan

[3] Univ Ioannina, Sch Med, Lab Mol Urol & Genet Human Reprod, Dept Urol, GR-45110 Ioannina, Greece

来源：

BJU INTERNATIONAL | 2010年 / 106卷 / 08期

关键词：

testis; Leydig cell; PDE5; inhibitors; sperm quality; SILDENAFIL CITRATE; SEMEN CHARACTERISTICS; SEMINAL PARAMETERS; TADALAFIL; RAT; SPERMATOGENESIS; TESTOSTERONE; VIAGRA(TM); MOTILITY;

D O I：

10.1111/j.1464-410X.2010.09243.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE To evaluate the effects of phosphodiesterase-5 inhibitors (PDE5-i) on Leydig cell secretory function (LCSF). PATIENTS AND METHODS In all, 75 men with oligoasthenospermia were treated daily for 12 weeks with either vardenafil (23 men, group A), sildenafil (25 men, group B) or l-carnitine (26 men, group C); a further group of 22 men with oligoasthenospermia (group D) received no treatment. Serum levels of insulin-like-3 peptide (INSL3) were evaluated before and after the end of the treatment in each of groups A, B and C, respectively. Serum INSL3 levels were measured in each participant of group D before and after the 12-week experimental period. RESULTS Within group A and B, the peripheral serum mean INSL3 concentration, sperm concentration, percentage of motile spermatozoa, and percentage of morphologically normal spermatozoa were significantly greater after PDE5-i treatment than before. CONCLUSION We suggest that PDE5-i enhances LCSF, as the mean INSL3 concentration was significantly greater after PDE5-i administration than before, within groups A and B. This enhancement in LCSF might contribute to the increase in sperm concentration and sperm motility after administration of PDE5-i.

引用

页码：1181 / 1185

页数：5

共 28 条

[1]

Ali ST, 2007, PAK J PHARM SCI, V20, P36

[2]

[Anonymous], 1999, WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction

[3] Effects of sildenafil (Viagra™) administration on seminal parameters and post-ejaculatory refractory time in normal males [J].

Aversa, A ;

Mazzilli, F ;

Rossi, T ;

Delfino, M ;

Isidori, AM ;

Fabbri, A .

HUMAN REPRODUCTION, 2000, 15 (01) :131-134

[4] Insulin-like factor 3 serum levels in 135 normal men and 85 men with testicular disorders:: Relationship to the luteinizing hormone-testosterone axis [J].

Bay, K ;

Hartung, S ;

Ivell, R ;

Schumacher, M ;

Jürgensen, D ;

Jorgensen, N ;

Holm, M ;

Skakkebaek, NE ;

Andersson, AM .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (06) :3410-3418

[5] SIMULTANEOUS RADIOIMMUNOASSAY OF PLASMA TESTOSTERONE AND DIHYDROTESTOSTERONE [J].

COYOTUPA, J ;

ABRAHAM, GE ;

PARLOW, AF .

ANALYTICAL LETTERS, 1972, 5 (06) :329-&

[6] Effects of phosphodiesterase 5 inhibitors on sperm parameters and fertilizing capacity [J].

Dimitriadis, F. ;

Giannakis, D. ;

Pardalidis, N. ;

Zikopoulos, K. ;

Paraskevaidis, E. ;

Giotitsas, N. ;

Kalaboki, V. ;

Tsounapi, P. ;

Baltogiannis, D. ;

Georgiou, I. ;

Saito, M. ;

Watanabe, T. ;

Miyagawa, I. ;

Sofikitis, N. .

ASIAN JOURNAL OF ANDROLOGY, 2008, 10 (01) :115-133

[7] Post-fertilization effects of chronic renal failure in male rats [J].

Dimitriadis, Fotios ;

Giannakis, Dimitrios ;

Giotitsas, Nikolaos ;

Parldalidis, Nikolaos ;

Baltogiannis, Dimitros ;

Saito, Motoaki ;

Watanabe, Takeshi ;

Gratsias, Stavros ;

Zikopoulos, Kostas ;

Pashopoulos, Minas ;

Tsambalas, Stavros ;

Kalaboki, Valentina ;

Tsounapi, Panagiota ;

Vlachopoulou, Evlalia ;

Gekas, Aristomenis ;

Melekos, Michael ;

Makridimas, George ;

Dalkalitsis, Nikolaos ;

Georgiou, Ioannis ;

Agapitos, Emmanuel ;

Loutradis, Dimitrios ;

Kanakas, Nikolaos ;

Miyagawa, Ikuo ;

Sofikitis, Nikolaos .

INTERNATIONAL JOURNAL OF ANDROLOGY, 2009, 32 (06) :675-686

[8] Effect of acute in vivo sildenafil citrate and in vitro 8-bromo-cGMP treatments on semen parameters and sperm function [J].

du Plessis, SS ;

de Jongh, PS ;

Franken, DR .

FERTILITY AND STERILITY, 2004, 81 (04) :1026-1033

[9] An evaluation of semen characteristics in men 45 years of age or older after daily dosing with tadalafil 20 mg: Results of a multicenter, randomized, double-blind, placebo-controlled, 9-month study [J].

Hellstrom, Wayne J. G. ;

Gittelman, Marc ;

Jarow, Jonathan ;

Steidle, Christopher ;

McMurray, James ;

Talley, David ;

Watts, Steven ;

Mitchell, Carol L. ;

McGill, James M. .

EUROPEAN UROLOGY, 2008, 53 (05) :1058-1065

[10] Tadalafil has no detrimental effect on human spermatogenesis or reproductive hormones [J].

Hellstrom, WJG ;

Overstreet, JW ;

Yu, A ;

Saikal, K ;

Shen, W ;

Beasley, CM ;

Watkins, VS .

JOURNAL OF UROLOGY, 2003, 170 (03) :887-891

← 1 2 3 →