Novel tumor necrosis factor-knockout mice that lack Peyer's patches

被引：65

作者：

Kuprash, DV

Tumanov, AV

Liepinsh, DJ

Koroleva, EP

Drutskaya, MS

Kruglov, AA

Shakhov, AN

Southon, E

Murphy, WJ

Tessarollo, L

Grivennikov, SL

Nedospasov, SA

机构：

[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Lab Mol Immunol, Moscow 119991, Russia

[2] NCI, Mol Immunoregulat Lab, Frederick, MD USA

[3] NCI, SAIC Frederick INc, Basic Res Program, Frederick, MD 21701 USA

[4] Univ Nevada, Sch Med, Dept Microbiol & Immunol, Reno, NV 89557 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2005年 / 35卷 / 05期

关键词：

cytokines; lymphoid organ development; host defense;

D O I：

10.1002/eji.200526119

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We generated a novel tumor necrosis factor (TNF) null mutation using Cre-loxP technology. Mice homozygous for this mutation differ from their "conventional" counterparts; in particular, they completely lack Peyer's patches (PP) but retain all lymph nodes. Our analysis of these novel TNF-knockout mice supports the previously disputed notion of the involvement of TNF-TNFR1 signaling in PP organogenesis. Availability of TNF-knockout strains both with and without PP enables more definitive studies concerning the roles of TNF and PP in various immune functions and disease conditions. Here, we report that systemic ablation of TNF, but not the presence of PP per se, is critical for protection against intestinal Listeria infection in mice.

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收藏

页码：1592 / 1600

页数：9

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