Evolution of prokaryotic gene order: genome rearrangements in closely related species

被引：119

作者：

Suyama, M

Bork, P

机构：

[1] European Mol Biol Lab, D-69012 Heidelberg, Germany

[2] Max Delbruck Ctr Mol Med, Berlin, Germany

来源：

TRENDS IN GENETICS | 2001年 / 17卷 / 01期

关键词：

D O I：

10.1016/S0168-9525(00)02159-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Conservation of gene order in prokaryotes has become important in predicting protein function because, over the evolutionary timescale, genomes are shuffled so that local gene-order conservation reflects the functional constraints within the protein. Here, we compare closely related genomes to identify the rate with which gene order is disrupted and to infer the genes involved in the genome rearrangement.

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页码：10 / 13

页数：4

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