Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model

被引：62

作者：

Trzcinski, K

Thompson, C

Malley, R

Lipsitch, M

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Immunol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Publ Hlth, Dept Infect Dis, Boston, MA 02115 USA

[4] Childrens Hosp, Dept Med, Div Infect Dis, Boston, MA 02115 USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 10期

关键词：

D O I：

10.1128/IAI.73.10.7043-7046.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In mice following intranasal exposure to Streptococcus pneumoniae, protection against pneumococcal colonization was independent of antibody but dependent on CD4(+) T cells. Nonetheless, concentrations of antibodies to three conserved pneumococcal antigens correlated with protection against colonization. Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection.

引用

收藏

页码：7043 / 7046

页数：4

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