A new FACIT of the collagen family: COL21A1

被引：59

作者：

Fitzgerald, J ^{[1
]}

Bateman, JF

机构：

[1] Univ Melbourne, Dept Paediat, Cell & Matrix Biol Res Unit, Parkville, Vic 3052, Australia

[2] Royal Childrens Hosp, MUrdoch Childrens Res Inst, Parkville, Vic 3052, Australia

来源：

FEBS LETTERS | 2001年 / 505卷 / 02期

基金：

英国医学研究理事会;

关键词：

fibril-associated collagen with interrupted triple; helices; von Willebrand factor A-domain; thrombospondin repeat; interrupted collagen triple helix; extracellular matrix;

D O I：

10.1016/S0014-5793(01)02754-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interrogation of the Human Genome data for sequences related to the von Willebrand factor A-domain module identified a previously unreported 4.1 kb full-length cDNA that is predicted to encode a new member of the collagen superfamily of extracellular matrix proteins, collagen XXI. The domain organization of collagen XXI comprised an N-terminal signal sequence, followed by single von Willebrand factor A-domain and thrombospondin domains, and an interrupted collagen triple helix. The organization of these motifs predict that collagen XXI is a new member of the FACIT collagen sub-family. Expression analysis indicated that COL21A1 mRNA is present in many tissues including heart, stomach, kidney, skeletal muscle and placenta, and radiation hybrid mapping localized the COL21A1 gene to 6p11-12. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：275 / 280

页数：6

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