A new FACIT of the collagen family: COL21A1

被引:59
作者
Fitzgerald, J [1 ]
Bateman, JF
机构
[1] Univ Melbourne, Dept Paediat, Cell & Matrix Biol Res Unit, Parkville, Vic 3052, Australia
[2] Royal Childrens Hosp, MUrdoch Childrens Res Inst, Parkville, Vic 3052, Australia
基金
英国医学研究理事会;
关键词
fibril-associated collagen with interrupted triple; helices; von Willebrand factor A-domain; thrombospondin repeat; interrupted collagen triple helix; extracellular matrix;
D O I
10.1016/S0014-5793(01)02754-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Interrogation of the Human Genome data for sequences related to the von Willebrand factor A-domain module identified a previously unreported 4.1 kb full-length cDNA that is predicted to encode a new member of the collagen superfamily of extracellular matrix proteins, collagen XXI. The domain organization of collagen XXI comprised an N-terminal signal sequence, followed by single von Willebrand factor A-domain and thrombospondin domains, and an interrupted collagen triple helix. The organization of these motifs predict that collagen XXI is a new member of the FACIT collagen sub-family. Expression analysis indicated that COL21A1 mRNA is present in many tissues including heart, stomach, kidney, skeletal muscle and placenta, and radiation hybrid mapping localized the COL21A1 gene to 6p11-12. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
引用
收藏
页码:275 / 280
页数:6
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