ANALYSIS OF ELECTRONIC CIGARETTE CARTRIDGES, REFILL SOLUTIONS, AND SMOKE FOR NICOTINE AND NICOTINE RELATED IMPURITIES

被引：187

作者：

Trehy, Michael L. ^{[1
]}

Ye, Wei ^{[1
]}

Hadwiger, Michael E. ^{[1
]}

Moore, Terry W. ^{[1
]}

Allgire, James F. ^{[1
]}

Woodruff, Jeffrey T. ^{[1
]}

Ahadi, Shafiq S. ^{[1
]}

Black, John C. ^{[1
]}

Westenberger, Benjamin J. ^{[1
]}

机构：

[1] US FDA, Div Pharmaceut Anal, St Louis, MO 63101 USA

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2011年 / 34卷 / 14期

关键词：

anatabine; cigarette; cotinine; e-cigarette; nicotine; smokeless; FREE-BASE NICOTINE; PARTICULATE MATTER; CHROMATOGRAPHY; DELIVERY;

D O I：

10.1080/10826076.2011.572213

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The objective of this study was to determine nicotine and the nicotine related impurities, that is, cotinine, myosmine, anatabine, anabasine, and beta-nicotyrine, in electronic cigarette cartridges, the liquid used to fill the cartridges, and from smoke generated using the electronic cigarette devices. An HPLC method was validated for the determination. Samples of nicotine containing products were purchased via the internet from NJOY, Smoking Everywhere, CIXI, and Johnson Creek. Electronic cigarette devices were purchased from NJOY, Smoking Everywhere, and CIXI. The results from the testing found that (1) the nicotine content labeling was not accurate with some manufacturers, (2) nicotine is present in the "smoke" from electronic cigarettes, and (3) nicotine related impurities contents in cartridges and refills were found to vary by electronic cigarette manufacturer.

引用

页码：1442 / 1458

页数：17

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