Prolyl endopeptidase inhibitors from green tea

被引：14

作者：

Kim, JH ^{[1
]}

Kim, SI ^{[1
]}

Song, KS ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Coll Agr, Dept Agr Chem, Taegu 702701, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2001年 / 24卷 / 04期

关键词：

prolyl endopeptidase inhibitor; green tea leaves; (-)-epigallocatechin gallate; (-)-epicatechin gallate; (+)-gallocatechin gallate;

D O I：

10.1007/BF02975094

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three prolyl endopeptidase (PEP) inhibitors were isolated from the methanolic extract of green tea leaves. They were identified as (-)-epigallocatechin gallate, (-)-epicatechin gallate, and (+)-gallocatechin gallate with the IC50 values of 1.42 x 10(-4) mM, 1.02 x 10(-2) mM, and 1.09 x 10(-4) mM, respectively. They were non-competitive with a substrate in Dixon plots and did not show any significant effects against other serine proteases such as elastase, trypsin, and chymotrypsin, suggesting that they were relatively specific inhibitors against PEP. The isolated compounds are expected to be useful for preventing and curing of Alzheimer's disease.

引用

页码：292 / 296

页数：5

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