Characterization of an HIV-1 p24(gag) epitope recognized by a CD8(+) cytotoxic T-cell clone

被引：7

作者：

Buseyne, F

Stevanovic, S

Rammensee, HG

Riviere, Y

机构：

[1] INST PASTEUR,UNITE VIROL & IMMUNOL CELLULAIRE,URA CNRS 1157,F-75724 PARIS 15,FRANCE

[2] INST ZELLBIOL,ABT IMMUNOL VERFUGUNGSGEBAUDE,D-72176 TUBINGEN,GERMANY

来源：

IMMUNOLOGY LETTERS | 1997年 / 55卷 / 03期

关键词：

cytotoxic T-lymphocyte; CTL epitope; HLA-C;

D O I：

10.1016/S0165-2478(97)02696-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A CD8(+) cytotoxic T-cell clone that recognized HIV p24(gag) isolated from an infected individual. The minimal epitope was localized to amino acids 308-316 (QASQEVKNW). Using allogeneic target cells, we found that lysis was restricted by the HLA-Cw0401 molecule. We observed that CIR cells, that express the HLA-Cw0401 allele are able to present the peptide to the cytotoxic clone, but with reduced efficiency. Other B-cell lines, that have been genotyped as HLA-Cw0401(+) were unable to present the peptide to the clone, suggesting the existence of other variants of HLA-Cw0401 or a loss of cell surface expression of this molecule. (C) 1997 Elsevier Science B.V.

引用

页码：145 / 149

页数：5

共 17 条

[1] High resolution HLA-C typing by PCR-SSP: Identification of allelic frequencies and linkage disequilibria in 604 unrelated random UK Caucasoids and a comparison with serology [J].

Bunce, M ;

Barnardo, MCNM ;

Procter, J ;

Marsh, SGE ;

Vilches, C ;

Welsh, KI .

TISSUE ANTIGENS, 1996, 48 (06) :680-691

[2]

BUSEYNE F, 1994, CLIN EXP IMMUNOL, V97, P353

[3]

BUSEYNE F, 1993, J IMMUNOL, V150, P3569

[4] GAG-SPECIFIC CYTOTOXIC T-LYMPHOCYTES FROM HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1-INFECTED INDIVIDUALS - GAG EPITOPES ARE CLUSTERED IN 3 REGIONS OF THE P24GAG PROTEIN [J].

BUSEYNE, F ;

MCCHESNEY, M ;

PORROT, F ;

KOVARIK, S ;

GUY, B ;

RIVIERE, Y .

JOURNAL OF VIROLOGY, 1993, 67 (02) :694-702

[5] PEPTIDE MOTIFS OF HLA-B51, HLA-B52 AND HLA-B78 MOLECULES, AND IMPLICATIONS FOR BEHCETS-DISEASE [J].

FALK, K ;

ROTZSCHKE, O ;

TAKIGUCHI, M ;

GNAU, V ;

STEVANOVIC, S ;

JUNG, G ;

RAMMENSEE, HG .

INTERNATIONAL IMMUNOLOGY, 1995, 7 (02) :223-228

[6] ALLELE-SPECIFIC PEPTIDE LIGAND MOTIFS OF HLA-C MOLECULES [J].

FALK, K ;

ROTZSCHKE, O ;

GRAHOVAC, B ;

SCHENDEL, D ;

STEVANOVIC, S ;

GNAU, V ;

JUNG, G ;

STROMINGER, JL ;

RAMMENSEE, HG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) :12005-12009

[7]

Johnson R P, 1994, Curr Top Microbiol Immunol, V189, P35

[8]

JOHNSON RP, 1991, J IMMUNOL, V147, P1512

[9] GENETIC-POLYMORPHISM WITHIN HLA-A-ASTERISK-02 - SIGNIFICANT ALLELIC VARIATION REVEALED IN DIFFERENT POPULATIONS [J].

KRAUSA, P ;

BRYWKA, M ;

SAVAGE, D ;

HUI, KM ;

BUNCE, M ;

NGAI, JLF ;

TEO, DLT ;

ONG, YW ;

BAROUCH, D ;

ALLSOP, CEM ;

HILL, AVS ;

MCMICHAEL, AJ ;

BODMER, JG ;

BROWNING, MJ .

TISSUE ANTIGENS, 1995, 45 (04) :223-231

[10] A CRITICAL ROLE FOR CONSERVED RESIDUES IN THE CLEFT OF HLA-A2 IN PRESENTATION OF A NONAPEPTIDE TO T-CELLS [J].

LATRON, F ;

PAZMANY, L ;

MORRISON, J ;

MOOTS, R ;

SAPER, MA ;

MCMICHAEL, A ;

STROMINGER, JL .

SCIENCE, 1992, 257 (5072) :964-967

← 1 2 →