Hypothetical protein KIAA0079 is a mammalian homologue of yeast Sec24p

被引：9

作者：

Tani, K ^{[1
]}

Oyama, Y ^{[1
]}

Hatsuzawa, K ^{[1
]}

Tagaya, M ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Life Sci, Hachioji, Tokyo 1920392, Japan

来源：

FEBS LETTERS | 1999年 / 447卷 / 2-3期

关键词：

Sec23p; Sec24p; coat protein II; endoplasmic reticulum; vesicular transport;

D O I：

10.1016/S0014-5793(99)00303-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Sec23p-Sec24p complex is a component of COPII-coated vesicles that mediate protein transport from the endoplasmic reticulum in yeast. The mammalian hypothetical protein KIAA0079 (KIAA0079p) exhibits sequence similarity to yeast Sec24p, KIAA0079p mas co-eluted with mammalian Sec23p on gel filtration. In vitro binding experiments revealed that the C-terminal region of KIAA0079p binds to the N-terminal region of mammalian Sec23p, Overexpression of KIAA0079p caused a defect in protein export from the endoplasmic reticulum, These results support the idea that KIAA0079p is a functional homologue of yeast Sec24p, (C) 1999 Federation of European Biochemical Societies.

引用

页码：247 / 250

页数：4

共 30 条

[1] Cargo selection by the COPII budding machinery during export from the ER [J].

Aridor, M ;

Weissman, J ;

Bannykh, S ;

Nuoffer, C ;

Balch, WE .

JOURNAL OF CELL BIOLOGY, 1998, 141 (01) :61-70

[2] COPII - A MEMBRANE COAT FORMED BY SEC PROTEINS THAT DRIVE VESICLE BUDDING FROM THE ENDOPLASMIC-RETICULUM [J].

BARLOWE, C ;

ORCI, L ;

YEUNG, T ;

HOSOBUCHI, M ;

HAMAMOTO, S ;

SALAMA, N ;

REXACH, MF ;

RAVAZZOLA, M ;

AMHERDT, M ;

SCHEKMAN, R .

CELL, 1994, 77 (06) :895-907

[3] COPII and selective export from the endoplasmic reticulum [J].

Barlowe, C .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1998, 1404 (1-2) :67-76

[4] Selective packaging of cargo molecules into endoplasmic reticulum-derived COPII vesicles [J].

Campbell, JL ;

Schekman, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (03) :837-842

[5] BETA-COP, A 110 KD PROTEIN ASSOCIATED WITH NON-CLATHRIN-COATED VESICLES AND THE GOLGI-COMPLEX, SHOWS HOMOLOGY TO BETA-ADAPTIN [J].

DUDEN, R ;

GRIFFITHS, G ;

FRANK, R ;

ARGOS, P ;

KREIS, TE .

CELL, 1991, 64 (03) :649-665

[6] YEAST SEC16 GENE ENCODES A MULTIDOMAIN VESICLE COAT PROTEIN THAT INTERACTS WITH SEC23P [J].

ESPENSHADE, P ;

GIMENO, RE ;

HOLZMACHER, E ;

TEUNG, P ;

KAISER, CA .

JOURNAL OF CELL BIOLOGY, 1995, 131 (02) :311-324

[7] COPII coat subunit interactions: Sec24p and Sec23p bind to adjacent regions of Sec16p [J].

Gimeno, RE ;

Espenshade, P ;

Kaiser, CA .

MOLECULAR BIOLOGY OF THE CELL, 1996, 7 (11) :1815-1823

[8] SEC23P AND A NOVEL 105-KDA PROTEIN FUNCTION AS A MULTIMERIC COMPLEX TO PROMOTE VESICLE BUDDING AND PROTEIN-TRANSPORT FROM THE ENDOPLASMIC-RETICULUM [J].

HICKE, L ;

YOSHIHISA, T ;

SCHEKMAN, R .

MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (06) :667-676

[9] YEAST SEC23P ACTS IN THE CYTOPLASM TO PROMOTE PROTEIN-TRANSPORT FROM THE ENDOPLASMIC-RETICULUM TO THE GOLGI-COMPLEX INVIVO AND INVITRO [J].

HICKE, L ;

SCHEKMAN, R .

EMBO JOURNAL, 1989, 8 (06) :1677-1684

[10] DISTINCT SETS OF SEC GENES GOVERN TRANSPORT VESICLE FORMATION AND FUSION EARLY IN THE SECRETORY PATHWAY [J].

KAISER, CA ;

SCHEKMAN, R .

CELL, 1990, 61 (04) :723-733

← 1 2 3 →