Body mass, tobacco smoking, alcohol drinking and risk of cancer of the small intestine-a pooled analysis of over 500 000 subjects in the Asia Cohort Consortium

被引：33

作者：

Boffetta, P. ^{[1
,2
,3
]}

Hazelton, W. D. ^{[4
]}

Chen, Y. ^{[5
]}

Sinha, R. ^{[6
]}

Inoue, M. ^{[7
]}

Gao, Y. T. ^{[8
]}

Koh, W. P. ^{[9
]}

Shu, X. O. ^{[10
]}

Grant, E. J. ^{[11
]}

Tsuji, I. ^{[12
]}

Nishino, Y. ^{[13
]}

You, S. L. ^{[14
]}

Yoo, K. Y. ^{[16
]}

Yuan, J. M. ^{[17
]}

Kim, J. ^{[18
]}

Tsugane, S. ^{[7
]}

Yang, G. ^{[10
]}

Wang, R. ^{[17
]}

Xiang, Y. B. ^{[8
]}

Ozasa, K. ^{[11
]}

Nagai, M. ^{[12
]}

Kakizaki, M. ^{[12
]}

Chen, C. J. ^{[15
,19
]}

Park, S. K. ^{[20
,21
]}

Shin, A. ^{[18
]}

Ahsan, H. ^{[22
,23
,24
,25
]}

Qu, C. X. ^{[26
,27
]}

Lee, J. E. ^{[28
]}

Thornquist, M. ^{[4
]}

Rolland, B. ^{[4
]}

Feng, Z. ^{[4
]}

Zheng, W. ^{[10
]}

Potter, J. D. ^{[4
,29
]}

机构：

[1] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Inst Translat Epidemiol, New York, NY 10029 USA

[3] Int Prevent Res Inst, Lyon, France

[4] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA

[5] NYU, Dept Environm Med, Sch Med, New York, NY 10016 USA

[6] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[7] Natl Canc Ctr, Epidemiol & Prevent Div, Res Ctr Canc Prevent & Screening, Tokyo 104, Japan

[8] Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China

[9] Natl Univ Singapore, Dept Epidemiol & Publ Hlth, Yong Loo Lin Sch Med, Singapore 117548, Singapore

[10] Vanderbilt Univ, Sch Med, Div Epidemiol,Vanderbilt Ingram Canc Ctr, Dept Med,Vanderbilt Epidemiol Ctr, Nashville, TN 37212 USA

[11] Radiat Effects Res Fdn, Dept Epidemiol, Hiroshima, Japan

[12] Tohoku Univ, Div Epidemiol, Dept Publ Hlth & Forens Med, Grad Sch Med, Sendai, Miyagi 980, Japan

[13] Miyagi Canc Ctr, Dept Epidemiol, Res Inst, Ishinomaki, Miyagi, Japan

[14] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan

[15] Natl Taiwan Univ, Genom Res Ctr, Acad Sinica, Taipei 10764, Taiwan

[16] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea

[17] Univ Minnesota, Mason Canc Ctr, Minneapolis, MN USA

[18] Natl Canc Ctr, Canc Epidemiol Branch, Seoul, South Korea

[19] Natl Taiwan Univ, Grad Inst Epidemiol, Coll Publ Hlth, Taipei 10764, Taiwan

[20] Seoul Natl Univ, Dept Prevent Med, Coll Med, Canc Res Inst, Seoul 151, South Korea

[21] Seoul Natl Univ, Dept Biomed Sci, Grad Sch, Seoul 151, South Korea

[22] Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA

[23] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[24] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA

[25] Univ Chicago, Canc Res Ctr, Chicago, IL 60637 USA

[26] Chinese Acad Med Sci, Beijing 100730, Peoples R China

[27] Peking Union Med Coll, Dept Canc Epidemiol, Canc Inst Hosp, Beijing 100021, Peoples R China

[28] Sookmyung Womens Univ, Seoul, South Korea

[29] Massey Univ, Ctr Publ Hlth Res, Wellington, New Zealand

来源：

ANNALS OF ONCOLOGY | 2012年 / 23卷 / 07期

基金：

新加坡国家研究基金会; 美国国家卫生研究院;

关键词：

alcohol drinking; body mass index; prospective studies; small intestine cancer; tobacco smoking; CIGARETTE-SMOKING; CROHNS-DISEASE; ADENOCARCINOMA; EPIDEMIOLOGY; POPULATION; METAANALYSIS; ASSOCIATION; OBESITY; INDEX;

D O I：

10.1093/annonc/mdr562

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The evidence for a role of tobacco smoking, alcohol drinking, and body mass index (BMI) in the etiology of small intestine cancer is based mainly on case-control studies from Europe and United States. We harmonized the data across 12 cohort studies from mainland China, Japan, Korea, Singapore, and Taiwan, comprising over 500 000 subjects followed for an average of 10.6 years. We calculated hazard ratios (HRs) for BMI and (only among men) tobacco smoking and alcohol drinking. A total of 134 incident cases were observed (49 adenocarcinoma, 11 carcinoid, 46 other histologic types, and 28 of unknown histology). There was a statistically non-significant trend toward increased HR in subjects with high BMI [HR for BMI > 27.5 kg/m(2), compared with 22.6-25.0, 1.50; 95% confidence interval (CI) 0.76-2.96]. No association was suggested for tobacco smoking; men drinking > 400 g of ethanol per week had an HR of 1.57 (95% CI 0.66-3.70), compared with abstainers. Our study supports the hypothesis that elevated BMI may be a risk factor for small intestine cancer. An etiologic role of alcohol drinking was suggested. Our results reinforce the existing evidence that the epidemiology of small intestine cancer resembles that of colorectal cancer.

引用

页码：1894 / 1898

页数：5

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