Ceramide: a contributor to insulin resistance or an innocent bystander?

被引：35

作者：

Boden, G. ^{[1
]}

机构：

[1] Temple Univ Hosp & Med Sch, Div Endocrinol Diabet & Metab, Philadelphia, PA 19140 USA

来源：

DIABETOLOGIA | 2008年 / 51卷 / 07期

关键词：

ceramide; diacylglycerol; inflammatory cytokines; insulin receptor substrate 1/2; insulin resistance; liposyn II; obesity; protein kinase C; protein kinase B; Akt; skeletal muscle;

D O I：

10.1007/s00125-008-1015-y

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

引用

页码：1095 / 1096

页数：2

共 12 条

[1]

Ceramide content is increased in skeletal muscle from obese insulin-resistant humans [J].

Adams, JM ;

Pratipanawatr, T ;

Berria, R ;

Wang, E ;

DeFronzo, RA ;

Sullards, MC ;

Mandarino, LJ .

DIABETES, 2004, 53 (01) :25-31

[2]

Free fatty acids in obesity and type 2 diabetes:: defining their role in the development of insulin resistance and β-cell dysfunction [J].

Boden, G ;

Shulman, GI .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2002, 32 :14-23

[3]

Boden Guenther, 2006, Expert Rev Endocrinol Metab, V1, P499, DOI 10.1586/17446651.1.4.499

[4]

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IκB-α [J].

Itani, SI ;

Ruderman, NB ;

Schmieder, F ;

Boden, G .

DIABETES, 2002, 51 (07) :2005-2011

[5]

Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance [J].

Liu, YY ;

Han, TY ;

Giuliano, AE ;

Hansen, N ;

Cabot, MC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (10) :7138-7143

[6]

Intracellular signal transduction pathways activated by ceramide and its metabolites [J].

Ruvolo, PP .

PHARMACOLOGICAL RESEARCH, 2003, 47 (05) :383-392

[7]

SKOVBRO M, 2008, DIABETOLOGIA

[8]

Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes [J].

Straczkowski, M. ;

Kowalska, I. ;

Baranowski, M. ;

Nikolajuk, A. ;

Otziomek, E. ;

Zabielski, P. ;

Adamska, A. ;

Blachnio, A. ;

Gorski, J. ;

Gorska, M. .

DIABETOLOGIA, 2007, 50 (11) :2366-2373

[9]

Ceramides in insulin resistance and lipotoxicity [J].

Summers, SA .

PROGRESS IN LIPID RESEARCH, 2006, 45 (01) :42-72

[10]

Minireview: Weapons of lean body mass destruction: The role of ectopic lipids in the metabolic syndrome [J].

Unger, RH .

ENDOCRINOLOGY, 2003, 144 (12) :5159-5165

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