Synthesis of novel chiral quaternary phosphonium salts with a multiple hydrogen-bonding site, and their application to asymmetric phase-transfer alkylation

被引：90

作者：

Manabe, K ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON | 1998年 / 54卷 / 48期

关键词：

asymmetric reactions; hydrogen bonding; phase transfer; phosphonium salts;

D O I：

10.1016/S0040-4020(98)00899-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral phosphonium salts having two NH and two OH groups as hydrogen-bond donors have been synthesized as novel phase-transfer catalysts, and used for asymmetric alkylation of beta-keto esters to give the corresponding products with up to 50% ee. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：14465 / 14476

页数：12

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