Formation of the head organizer in hydra involves the canonical Wnt pathway

被引：195

作者：

Broun, M

Gee, L

Reinhardt, B

Bode, HR ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Ctr Dev Biol, Irvine, CA 92697 USA

来源：

DEVELOPMENT | 2005年 / 132卷 / 12期

关键词：

hydra; head organizer; canonical Wnt pathway;

D O I：

10.1242/dev.01848

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Stabilization of beta-catenin by inhibiting the activity of glycogen synthase kinase-3 beta has been shown to initiate axis formation or axial patterning processes in many bilaterians. In hydra, the head organizer is located in the hypostome, the apical portion of the head. Treatment of hydra with alsterpaullone, a specific inhibitor of glycogen synthase kinase-3 beta, results in the body column acquiring characteristics of the head organizer, as measured by transplantation experiments, and by the expression of genes associated with the head organizer. Hence, the role of the canonical Wnt pathway for the initiation of axis formation was established early in metazoan evolution.

引用

收藏

页码：2907 / 2916

页数：10

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