The B-cell epitope of the monoclonal anti-factorVIII antibody ESH8 characterized by peptide array analysis

被引：13

作者：

Albert, Thilo ^{[1
]}

Egler, Christian ^{[2
]}

Jakuschev, Stanislav ^{[3
]}

Schuldenzucker, Ulrike ^{[2
]}

Schmitt, Alexandra ^{[1
]}

Brokemper, Oliver ^{[2
]}

Zabe-Kuehn, Martin ^{[2
]}

Hoffmann, Daniel ^{[2
,3
]}

Oldenburg, Johannes ^{[1
]}

Schwaab, Rainer ^{[1
]}

机构：

[1] Univ Clin Bonn, Inst Expt Haematol & Tranfus Med, D-53127 Bonn, Germany

[2] Ctr Adv European Studies & Res, Bonn, Germany

[3] Univ Duisburg Essen, Ctr Med Biotechnol, Dept Bioinformat, Essen, Germany

来源：

THROMBOSIS AND HAEMOSTASIS | 2008年 / 99卷 / 03期

关键词：

D O I：

10.1160/TH07-06-0400

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：634 / 637

页数：4

共 13 条

[1] Role of the C2 domain of factor VIIIa in the assembly of factor-X activating complex on the platelet membrane [J].

Ahmad, SS ;

Walsh, PN .

BIOCHEMISTRY, 2005, 44 (42) :13858-13865

[2]

GRIFFIN BD, 1986, THROMB HAEMOSTASIS, V55, P40

[3] Mapping of FVIII inhibitor epitopes using cellulose-bound synthetic peptide arrays [J].

Kopecky, EM ;

Greinstetter, S ;

Pabinger, I ;

Buchacher, A ;

Römisch, J ;

Jungbauer, A .

JOURNAL OF IMMUNOLOGICAL METHODS, 2006, 308 (1-2) :90-100

[4]

Myszyka DG, 1999, J MOL RECOGNIT, V12, P279, DOI 10.1002/(SICI)1099-1352(199909/10)12:5<279::AID-JMR473>3.0.CO

[5]

2-3

[6] Role of factor VIIIC2 domain in factor VIII binding to factor Xa [J].

Nogami, K ;

Shima, M ;

Hosokawa, K ;

Suzuki, T ;

Koide, T ;

Saenko, EL ;

Scandella, D ;

Shibata, M ;

Kamisue, S ;

Tanaka, I ;

Yoshioka, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (43) :31000-31007

[7] Antifactor VIII antibody inhibiting allogeneic but not antologous factor VIII in patients with mild hemophilia A [J].

Peerlinck, K ;

Jacquemin, MG ;

Arnout, J ;

Hoylaerts, MF ;

Gilles, JGG ;

Lavend'homme, R ;

Johnson, KM ;

Freson, K ;

Scandella, D ;

Saint-Remy, JMR ;

Vermylen, J .

BLOOD, 1999, 93 (07) :2267-2273

[8] Structure of the C2 domain of human factor VIII at 1.5 Å resolution [J].

Pratt, KP ;

Shen, BW ;

Takeshima, K ;

Davie, EW ;

Fujikawa, K ;

Stoddard, BL .

NATURE, 1999, 402 (6760) :439-442

[9] Activation of factor VIII by thrombin increases its affinity for binding to synthetic phospholipid membranes and activated platelets [J].

Saenko, EL ;

Scandella, D ;

Yakhyaev, AV ;

Greco, NJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (43) :27918-27926

[10] Slowed release of thrombin-cleaved factor VIII from von Willebrand factor by a monoclonal and a human antibody is a novel mechanism for factor VIII inhibition [J].

Saenko, EL ;

Shima, M ;

Gilbert, M ;

Scandella, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (44) :27424-27431

← 1 2 →