Xanthones as inhibitors of Epstein-Barr virus activation

被引：39

作者：

Ito, C

Itoigawa, M ^{[1
]}

Furukawa, H

Rao, KS

Enjo, F

Bu, P

Takayasu, J

Tokuda, H

Nishino, H

机构：

[1] Tokai Gakuen Univ, Aichi 4700207, Japan

[2] Meijo Univ, Fac Pharm, Tempa Ku, Nagoya, Aichi 4680077, Japan

[3] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020000, Japan

[4] Univ Papua New Guinea, Dept Chem, Port Moresby, Papua N Guinea

来源：

CANCER LETTERS | 1998年 / 132卷 / 1-2期

关键词：

antitumor promoting effect; Epstein-Barr virus activation test; xanthones; structure-activity relationships;

D O I：

10.1016/S0304-3835(98)00173-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To search for possible antitumor promoters, we carried out a primary screening of 20 xanthones isolated from plants of the Guttiferae family, using their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Some of these xanthones, namely 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)xanthone (8), dulxanthone-B (10) and latisxanthone-C (15), were observed to significantly inhibit the EBV-EA activation. The investigation indicated that 8, 10 and 15 might be valuable antitumor promoters. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：113 / 117

页数：5

共 11 条

[1] XANTHONES FROM GUTTIFERAE [J].