Molecular mechanism of a cross-talk between estrogen and growth-factor signaling pathways

被引：37

作者：

Kato, S ^{[1
]}

Kitamoto, T ^{[1
]}

Masuhiro, Y ^{[1
]}

Yanagisawa, J ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

来源：

ONCOLOGY | 1998年 / 55卷

关键词：

estrogen receptor; transcription; mitogen-activated protein kinase; co-activator; transactivation domain;

D O I：

10.1159/000055253

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The actions of estrogen (E-2) are considered to be mediated through its nuclear E-2 receptor (ER). In cancer development, growth factors are shown to act synergistically with E-2. Recently we found that the mitogen-activated protein kinase, activated by growth factors, phosphorylates human ER alpha and this phosphorylation potentiates the transactivation function of human ER alpha demonstrating a novel cross-talk between E-2 and growth factor-signaling pathways. In this review, the molecular mechanism of this cross-talk is discussed.

引用

页码：5 / 10

页数：6

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