Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development

被引：157

作者：

Freiman, RN

Albright, SR

Zheng, S

Sha, WC

Hammer, RE

Tjian, R

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

[3] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

[4] Univ Texas, SW Med Ctr, Green Ctr Reprod Biol Sci, Dallas, TX 75390 USA

来源：

SCIENCE | 2001年 / 293卷 / 5537期

关键词：

D O I：

10.1126/science.1061935

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transcription factor TFIID, composed of TBP and TAF(11) subunits, is a central component of the RNA polymerase II machinery. Here, we report that the tissue-selective TAF(11)105 subunit of TFIID is essential for proper development and function of the mouse ovary. Female mice lacking TAF(11)105 are viable but infertile because of a defect in folliculogenesis correlating with restricted expression of TAF(11)105 in the granulosa cells of the ovarian follicle. Gene expression profiling has uncovered a defective inhibin-activin signaling pathway in TAF(11)105-deficient ovaries. Together, these studies suggest that TAF(11)105 mediates the transcription of a subset of genes required for proper folliculogenesis in the ovary and establishes TAF(11)105 as a cell type-specific component of the mammalian transcriptional machinery.

引用

页码：2084 / 2087

页数：4

共 19 条

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