Serum-stable and long-circulating, PEGylated, pH-sensitive liposomes

被引：64

作者：

Roux, E

Passirani, C

Scheffold, S

Benoit, JP

Leroux, JC

机构：

[1] Univ Montreal, Fac Pharm, Canada Res Chair Drug Delivery, Montreal, PQ H3C 3J7, Canada

[2] Univ Angers, INSERM, ERITM0104, F-49100 Angers, France

来源：

JOURNAL OF CONTROLLED RELEASE | 2004年 / 94卷 / 2-3期

基金：

加拿大健康研究院;

关键词：

pH-sensitive liposomes; poly(N-isopropylacrylamide); poly(ethylene glycol);

D O I：

10.1016/j.jconrel.2003.10.024

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

pH-sensitive liposomes were prepared using a terminally-alkylated copolymer of N-isopropylacrylamide (NIPAM) and methacrylic acid (MAA) and poly(ethylene glycol) (PEG) phospholipid derivative. The pH-triggered content release was evaluated before and after incubation in serum. Pharmacokinetic and biodistribution profiles of the formulations were established in rats. This study showed that a pH-sensitive, serum-stable and long-circulating liposomal formulation can be produced.

引用

收藏

页码：447 / 451

页数：5

相关论文

共 17 条

[1] Proton-induced permeability and fusion of large unilamellar vesicles by covalently conjugated poly(2-ethylacrylic acid) [J].

Chen, T ;

Choi, LS ;

Einstein, S ;

Klippenstein, MA ;

Scherrer, P ;

Cullis, PR .

JOURNAL OF LIPOSOME RESEARCH, 1999, 9 (03) :387-405

[2] STRUCTURAL AND FUNCTIONAL COMPARISONS OF PH-SENSITIVE LIPOSOMES COMPOSED OF PHOSPHATIDYLETHANOLAMINE AND 3 DIFFERENT DIACYLSUCCINYLGLYCEROLS [J].

COLLINS, D ;

LITZINGER, DC ;

HUANG, L .

BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1025 (02) :234-242

[3] BIODISTRIBUTION OF PH-SENSITIVE IMMUNOLIPOSOMES [J].

CONNOR, J ;

NORLEY, N ;

HUANG, L .

BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 884 (03) :474-481

[4] PH-SENSITIVE LIPOSOMES - ACID-INDUCED LIPOSOME FUSION [J].

CONNOR, J ;

YATVIN, MB ;

HUANG, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (06) :1715-1718

[5] Current status of pH-sensitive liposomes in drug delivery [J].

Drummond, DC ;

Zignani, M ;

Leroux, JC .

PROGRESS IN LIPID RESEARCH, 2000, 39 (05) :409-460

[6] PH-INDUCED DESTABILIZATION OF "PHOSPHATIDYLETHANOLAMINE-CONTAINING LIPOSOMES - ROLE OF BILAYER CONTACT [J].

ELLENS, H ;

BENTZ, J ;

SZOKA, FC .

BIOCHEMISTRY, 1984, 23 (07) :1532-1538

[7] A MONOCLONAL-ANTIBODY REACTIVE WITH NORMAL AND LEUKEMIC HUMAN MYELOID PROGENITOR CELLS [J].

GRIFFIN, JD ;

LINCH, D ;

SABBATH, K ;

LARCOM, P ;

SCHLOSSMAN, SF .

LEUKEMIA RESEARCH, 1984, 8 (04) :521-534

[8] NOVEL PH-SENSITIVE LIPOSOMES - LIPOSOMES BEARING A POLY(ETHYLENE GLYCOL) DERIVATIVE WITH CARBOXYL GROUPS [J].

KONO, K ;

ZENITANI, K ;

TAKAGISHI, T .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1994, 1193 (01) :1-9

[9] Copolymers of N-isopropylacrylamide can trigger pH sensitivity to stable liposomes [J].

Meyer, O ;

Papahadjopoulos, D ;

Leroux, JC .

FEBS LETTERS, 1998, 421 (01) :61-64

[10] On the characterization of pH-sensitive liposome/polymer complexes [J].

Roux, E ;

Lafleur, M ;

Lataste, É ;

Moreau, P ;

Leroux, JC .

BIOMACROMOLECULES, 2003, 4 (02) :240-248