Synthesis and biological evaluation of novel bisindolylmaleimides that inhibit vascular endothelial cell proliferation

被引:13
作者
Braña, MF [1 ]
Añorbe, L
Tarrasón, G
Mitjans, F
Piulats, J
机构
[1] Univ San Pablo CEU, Fac CC Expt & Tecnicas, Dept Quim Organ & Farmaceut, Madrid 28668, Spain
[2] Merck Farma & Quim SA, Lab Bioinvest, Casp 108, Barcelona 08010, Spain
关键词
D O I
10.1016/S0960-894X(01)00535-2
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A novel class of bisindolylmaleimides were synthesized and antiproliferative activities (HUVECs and three tumor cell lines) of these compounds were investigated. Two water-soluble derivatives, 10 and 12, possessing a dimethylaminoalkoxy side chain in their structure, showed interesting activity and selectivity on HUVECs proliferation, (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2701 / 2703
页数:3
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