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Cannabinoid type 1 receptor: Another arrow in the adipocytes' bow

被引：56
作者：
Bellocchio, L. [1 ,2 ]
Cervino, C. [1 ,2 ]
Vicennati, V. [1 ,2 ]
Pasquali, R. [1 ,2 ]
Pagotto, U. [1 ,2 ]
机构：
[1] Univ Bologna, S Orsola Malpighi Hosp,Alma Mater Studiorum, Dept Internal Med & Gastroenterol, Endocrinol Unit, I-40138 Bologna, Italy
[2] Univ Bologna, S Orsola Malpighi Hosp,Alma Mater Studiorum, Dept Internal Med & Gastroenterol, CRBA, I-40138 Bologna, Italy
来源：
JOURNAL OF NEUROENDOCRINOLOGY | 2008年 / 20卷
关键词：
cannabinoid receptor type 1; rimonabant; adipocyte; adipose tissue; obesity;
D O I：
10.1111/j.1365-2826.2008.01682.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The endocannabinoid system has recently emerged as an important modulator of several functions of adipose tissue, including cell proliferation, differentiation and secretion. Here, we will review the effects of cannabinoid type 1 (CB1) receptor activation/blockade in adipocytes by summarising the data in the literature since the discovery of the presence of this receptor in adipose tissue. We will also discuss our original data obtained in mouse 3T3-L1 adipocyte cells using WIN55 212, a CB1/CB2 receptor agonist and SR141716 (rimonabant), a specific CB1 receptor antagonist, respectively, in different experimental settings.
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页码：130 / 138
页数：9
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