A key intermediate for the convenient synthesis of series of vitamin D3 analogues with modified side chains

被引：6

作者：

Fall, Y ^{[1
]}

Fernandez, C

González, V

Mouriño, A

机构：

[1] Univ Vigo, Fac Ciencias, Dept Quim Organ, Vigo 36200, Spain

[2] Univ Santiago de Compostela, CSIC, Dept Quim Organ, Santiago De Compostela 15782, Spain

[3] Univ Santiago de Compostela, CSIC, Unidad Asociada, Santiago De Compostela 15782, Spain

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 44期

关键词：

D O I：

10.1016/S0040-4039(01)01673-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tosylate 1, which features the vitamin D triene unit, was stereoselectively synthesized from commercially available starting materials. This key intermediate undergoes a very efficient one-pot, two-step reaction with tetrabutyl ammonium fluoride to afford vitamin D analogue 2, which bears a cyclic side chain. Reaction of 1 with lithium aluminium hydride and removal of the silyl protecting groups affords the 22-methylated vitamin D analogue 3. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：7815 / 7817

页数：3

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