Conformation of peroxynitrite:: Determination by crystallographic analysis

被引：23

作者：

Wörle, M ^{[1
]}

Latal, P ^{[1
]}

Kissner, R ^{[1
]}

Nesper, R ^{[1
]}

Koppenol, WH ^{[1
]}

机构：

[1] ETH Zurich, Anorgan Chem Lab, CH-8092 Zurich, Switzerland

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 1999年 / 12卷 / 04期

关键词：

D O I：

10.1021/tx990013u

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Peroxynitrite is an inorganic toxin of biological importance. It is formed in vivo from the diffusion-limited reaction of nitrogen monoxide with superoxide. Due to the partial double bond between the nitrogen and the first peroxide oxygen, peroxynitrite can occur in two conformations, cis and trans. The synthesis of tetramethylammonium peroxynitrite in ammonia [Bohle, D. S., et al. (1994) J. Am. Chem. Sec. 116, 7423-7424] yields small crystals if the ammonia is left to evaporate slowly. X-ray structure analysis shows that peroxynitrite crystallizes in the cis form, relative to the N-O bond. Crystal twinning or disorder prevents the determination of accurate bond lengths and bond angles. However, a nearly flat (torsion angle of 22 degrees) molecule with O=N, N-O, and O-O bond lengths of 1.16, 1.35, and 1.41 Angstrom, respectively, would fit the observed electron density best. The space group of tetramethylammonium peroxynitrite is Pmmm (59), and it has the following unit cell dimensions: a = 7.1778(11) Angstrom, b = 8.6893(13) Angstrom, and c = 5.7266(9) Angstrom.

引用

页码：305 / 307

页数：3

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