Putting a finger on the switch

被引：19

作者：

Bieker, James J. ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Dev & Regenerat Biol, New York, NY 10029 USA

来源：

NATURE GENETICS | 2010年 / 42卷 / 09期

关键词：

KRUPPEL-LIKE FACTOR; GLOBIN;

D O I：

10.1038/ng0910-733

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The transition from fetal to adult beta-like globin expression is a key step in the maturation of the red blood cell lineage. Two new studies show that the KLF1 zinc finger protein uses direct and indirect means to regulate the final switch from fetal to adult globin expression and that monoallelic loss of KLF1 expression leads to persistence of fetal hemoglobin.

引用

页码：733 / 734

页数：2

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