Dendritic cells in immunity and tolerance - Do they display opposite functions?

被引：206

作者：

Moser, M ^{[1
]}

机构：

[1] Free Univ Brussels, Inst Biol & Med Mol, Physiol Anim Lab, B-6041 Gosselies, Belgium

来源：

IMMUNITY | 2003年 / 19卷 / 01期

关键词：

IN-VIVO; LYMPH-NODES; T-CELLS; ANTIGEN; LEADS; MICE;

D O I：

10.1016/S1074-7613(03)00182-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It was recently proposed that cells of the dendritic family not only control immunity but also maintain tolerance to self-antigens, two complementary functions that would ensure the integrity of the organism in an environment full of pathogens. As they express a variety of receptors that specifically recognize microbial products, DCs are able to discriminate between self and nonself and may therefore enable the immune system to mount potent effector activity to pathogens while silencing self-reactive lymphocytes.

引用

页码：5 / 8

页数：4

共 21 条

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