Effect of long-term olive oil dietary intervention on postprandial triacylglycerol and factor VII metabolism

被引:118
作者
Roche, HM
Zampelas, A
Knapper, JME
Webb, D
Brooks, C
Jackson, KG
Wright, JW
Gould, BJ
Kafatos, A
Gibney, MJ
Williams, CM
机构
[1] St James Hosp, Trin Ctr Hlth Sci, Dept Clin Med, Nutr Unit, Dublin 8, Ireland
[2] Univ Surrey, Sch Biol Sci, Guildford GU2 5XH, Surrey, England
[3] Univ Reading, Dept Food Sci & Technol, Hugh Sinclair Unit Human Nutr, Reading RG6 2AH, Berks, England
[4] Univ Crete, Prevent Med & Nutr Clin, Dept Social Med, Crete, Greece
关键词
triacylglycerol; factor VII; cholesterol; postprandial lipemia; monounsaturated fatty acids; MUFAs; saturated fatty acids; SFAs; dietary fat; Mediterranean diet; olive oil; men;
D O I
10.1093/ajcn/68.3.552
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Although the beneficial effects of Mediterranean-type diets, which are rich in olive oil, a good source of monounsaturated acids (MUFAs), are generally accepted, little is known about the effects of long-term dietary MUFA intake on postprandial lipoprotein metabolism and hemostasis. This study used a single-blind, randomized, crossover design to investigate the relative effects of a long-term dietary olive oil intervention and a control [saturated fatty acid (SFA)-enriched] diet on postprandial triacylglycerol metabolism and factor VII activity. The postprandial response to a standard test meal was investigated in 23 healthy men who adhered to both diets for 8 wk. cis-MUFAs were successfully substituted for SFAs in the MUFA diet without affecting total dietary fat or energy intakes. The long-term dietary MUFA intervention significantly reduced plasma and LDL-cholesterol concentrations (P = 0.01). Postprandial triacylglycerol concentrations were significantly greater in the early postprandial period after the MUFA diet (P = 0.003). Postprandial factor VII activation and the concentration of the factor VII antigen were significantly lower after the MUFA diet (P = 0.04 and P = 0 006, respectively). This study showed that isoenergetic substitution of MUFAs for SFAs reduces plasma cholesterol and reduces the degree of postprandial factor VII activation. The alterations in the postprandial triacylglycerol response suggest a greater rate of dietary fat absorption and postprandial triacylglycerol metabolism after a diet rich in MUFAs. This study presents new insights into the biochemical basis of the beneficial effects associated with long-term dietary MUFA consumption, which may explain the lower rates of coronary mortality in Mediterranean regions.
引用
收藏
页码:552 / 560
页数:9
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