Four-component reactions for a new diastereoselective synthesis of chiral quaternary centers

被引：70

作者：

Sklute, G

Amsallem, D

Shabli, A

Varghese, JP

Marek, I ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Dept Chem, IL-32000 Haifa, Israel

[2] Technion Israel Inst Technol, Inst Catalysis Sci & Technol, IL-32000 Haifa, Israel

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 39期

关键词：

D O I：

10.1021/ja036872t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The one-pot preparation of chiral homoallylic alcohol and amine derivatives was easily achieved by carbocupration of alkynyl sulfoxides followed by an in situ zinc homologation and reaction with aldehydes or imines. In this process, three new carbon-carbon bonds were created as well as quaternary and tertiary chiral centers with excellent diastereo- and enantioselectivities. Copyright © 2003 American Chemical Society.

引用

页码：11776 / 11777

页数：2

共 37 条

[1]

ACHYUTHARAO S, 1993, J ORG CHEM, V58, P2694

[2] OPTICALLY ACTIVE SULFOXIDES . SYNTHESIS + ROTATORY DISPERSION OF SOME DIARYL SULFOXIDES [J].