Development of macrolide resistance by ribosomal protein L4 mutation in Streptococcus pyogenes during miocamycin treatment of an eight-year-old Greek child with tonsillopharyngitis

被引：7

作者：

Bozdogan, B ^{[1
]}

Appelbaum, PC

Ednie, L

Grivea, IN

Syrogiannopoulos, GA

机构：

[1] Penn State Univ, Milton S Hershey Med Ctr, Dept Pathol, Hershey, PA 17033 USA

[2] Univ Patras, Sch Med, Dept Pediat, GR-26110 Patras, Greece

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2003年 / 9卷 / 09期

关键词：

Streptococcus pyogenes; macrolide resistance; ribosomal mutation;

D O I：

10.1046/j.1469-0691.2003.00670.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Streptococcus pyogenes isolates with the same pulsed-field patterns were recovered from the throat cultures of a child with tonsillopharyngitis before and after treatment with miocamycin, a 16-membered macrolide. The initial isolate was macrolide-susceptible, but the isolates after the treatment were resistant to 14 and 15-membered macrolides and had two amino acid (65WR66) deletions in ribosomal protein L4.

引用

页码：966 / 969

页数：4

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