Intracellular spatial control of fluorescent magnetic nanoparticles

被引：233

作者：

Gao, Jinhao ^{[1
]}

Zhang, Wei ^{[2
]}

Huang, Pingbo ^{[2
]}

Zhang, Bei ^{[3
]}

Zhang, Xixiang ^{[3
]}

Xu, Bing ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Dept Biol, Hong Kong, Hong Kong, Peoples R China

[3] Hong Kong Univ Sci & Technol, Dept Phys, Hong Kong, Hong Kong, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 12期

关键词：

D O I：

10.1021/ja7103125

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a facile intracellular manipulation of fluorescent magnetic Fe3O4-CdSe nanoparticles using magnetic force. The growth of CdSe quantum dots on Fe3O4 nanoparticles produces Fe3O4-CdSe nanoparticles with two distinct properties, fluorescence and superparamagnetism. After nonspecific surface modification using glutathione (GSH), the hydrophilic Fe3O4-CdSe@GSH nanoparticles can be easily uptaken by an HEK293T cell line. Conlocal images indicate that the uptaken nanoparticles can be manipulated using a small magnet. The successful intracellular manipulation of magnetic nanoparticles may offer a new strategy for studying polarized cells.

引用

页码：3710 / +

页数：3

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