On the antioxidant activity of melatonin

被引：118

作者：

Antunes, F

Barclay, LRC ^{[1
]}

Ingold, KU

King, M

Norris, JQ

Scaiano, JC

Xi, FD

机构：

[1] Mt Allison Univ, Dept Chem, Sackville, NB E4L 1G8, Canada

[2] Grp Bioquim & Biol Teor, P-1250 Lisbon, Portugal

[3] Natl Res Council Canada, Steacie Inst Mol Sci, Ottawa, ON K1A 0R6, Canada

[4] Univ Ottawa, Dept Chem, Ottawa, ON K1N 6N5, Canada

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1999年 / 26卷 / 1-2期

基金：

加拿大自然科学与工程研究理事会;

关键词：

melatonin; antioxidant; free radicals; metal chelation;

D O I：

10.1016/S0891-5849(98)00168-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Melatonin has been widely reported to be an effective antioxidant. Studies of its ability to inhibit the autoxidation of lipids in homogeneous solution and in model heterogeneous systems show that melatonin is not a peroxyl radical trapping antioxidant. In contrast, melatonin can inhibit metal ion-catalyzed oxidation processes. (C) 1998 Elsevier Science Inc.

引用

页码：117 / 128

页数：12

共 58 条

[1] Antioxidant role of melatonin in lipid peroxidation of human LDL
Abuja, PM
Liebmann, P
Hayn, M
Schauenstein, K
Esterbauer, H
[J]. FEBS LETTERS, 1997, 413 (02) : 289 - 293
[2] Neurohormone melatonin prevents cell damage: Effect on gene expression for antioxidant enzymes
Antolin, I
Rodriguez, C
Sainz, RM
Mayo, JC
Uria, H
Kotler, MI
RodriguezColunga, MJ
Tolivia, D
MenendezPelaez, A
[J]. FASEB JOURNAL, 1996, 10 (08) : 882 - 890
[3] AUTOXIDATION IN MICELLES - SYNERGISM OF VITAMIN-C WITH LIPID-SOLUBLE VITAMIN-E AND WATER-SOLUBLE TROLOX
BARCLAY, LRC
LOCKE, SJ
MACNEIL, JM
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1985, 63 (02): : 366 - 374
[4] PARTITIONING AND ANTIOXIDANT ACTION OF THE WATER-SOLUBLE ANTIOXIDANT, TROLOX, BETWEEN THE AQUEOUS AND LIPID PHASES OF PHOSPHATIDYLCHOLINE MEMBRANES - C-14 TRACER AND PRODUCT STUDIES
BARCLAY, LRC
ARTZ, JD
MOWAT, JJ
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1995, 1237 (01): : 77 - 85
[5] Photo-initiated peroxidation of lipids in micelles by azaaromatics
Barclay, LRC
Crowe, E
Edwards, CD
[J]. LIPIDS, 1997, 32 (03) : 237 - 245
[6] CHAIN-BREAKING PHENOLIC ANTIOXIDANTS - STERIC AND ELECTRONIC EFFECTS IN POLYALKYLCHROMANOLS, TOCOPHEROL ANALOGS, HYDROQUINONES, AND SUPERIOR ANTIOXIDANTS OF THE POLYALKYLBENZOCHROMANOL AND NAPHTHOFURAN CLASS
BARCLAY, LRC
VINQVIST, MR
MUKAI, K
ITOH, S
MORIMOTO, H
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (26) : 7416 - 7420
[7] AUTOXIDATION OF MICELLES AND MODEL MEMBRANES - QUANTITATIVE KINETIC MEASUREMENTS CAN BE MADE BY USING EITHER WATER-SOLUBLE OR LIPID-SOLUBLE INITIATORS WITH WATER-SOLUBLE OR LIPID-SOLUBLE CHAIN-BREAKING ANTIOXIDANTS
BARCLAY, LRC
LOCKE, SJ
MACNEIL, JM
VANKESSEL, J
BURTON, GW
INGOLD, KU
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (08) : 2479 - 2481
[8] Bertuglia S, 1996, CARDIOVASC RES, V31, P947
[9] TOCOPHEROL-MEDIATED PEROXIDATION - THE PROOXIDANT EFFECT OF VITAMIN-E ON THE RADICAL-INITIATED OXIDATION OF HUMAN LOW-DENSITY-LIPOPROTEIN
BOWRY, VW
STOCKER, R
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (14) : 6029 - 6044
[10] INHIBITED AUTOXIDATION OF STYRENE .6. RELATIVE EFFICIENCIES AND KINETICS FOR INHIBITION BY N-ARYL ANILINES AND N-ALKYL ANILINES
BROWNLIE, IT
INGOLD, KU
[J]. CANADIAN JOURNAL OF CHEMISTRY, 1967, 45 (20): : 2419 - &

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