Widespread sequence variation in Epstein-Barr virus nuclear antigen 1 influences the antiviral T cell response

被引：27

作者：

Bell, Melissa J.

Brennan, Rebekah ^{[2
]}

Miles, John J. ^{[3
]}

Moss, Denis J.

Burrows, Jacqueline M.

Burrows, Scott R. ^{[1
]}

机构：

[1] Queensland Inst Med Res, Cellular Immunol Lab, Brisbane, Qld 4029, Australia

[2] Univ Queensland, Sch Med, Brisbane, Qld, Australia

[3] Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 197卷 / 11期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1086/587848

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Epstein-Barr virus (EBV) nuclear antigen (EBNA) 1 is perhaps the most widely studied EBV protein, because of its critical role in maintaining the EBV episome and its expression in all EBV-associated malignancies. Much of this research has focused exclusively on the EBV wild-type (wt) strain (B95-8). Sequence analysis of the gene encoding for EBNA1 in EBV isolates from 43 Caucasians has now revealed considerable EBNA1 sequence divergence from the EBV wt strain in the majority of isolates from this population group. Importantly, T cell recognition of an endogenously processed HLA-B8-binding EBNA1 epitope was greatly influenced by this sequence polymorphism.

引用

收藏

页码：1594 / 1597

页数：4

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