Effects of isolation rearing on startle reactivity, habituation, and prepulse inhibition in male Lewis, Sprague-Dawley, and Fischer F344 rats

被引：90

作者：

Varty, GB ^{[1
]}

Geyer, MA ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

来源：

BEHAVIORAL NEUROSCIENCE | 1998年 / 112卷 / 06期

关键词：

D O I：

10.1037/0735-7044.112.6.1450

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

This study compared the interaction of strain with isolation rearing on startle reactivity, habituation, and prepulse inhibition (PPI) in male Lewis, Sprague-Dawley, and Fischer F344 rats tested as adults. Lewis and Fischer rats exhibited lower startle reactivity than Sprague-Dawley rats. Lewis rats displayed more rapid habituation than the other strains. Most important, isolation rearing produced deficits in PPI in both Sprague-Dawley and Fischer rats but had no effect in Lewis rats. By contrast, isolation rearing had no effect on startle reactivity or habituation. In a separate study, 0.5 mg/kg apomorphine disrupted PPI in Fischer but not in Lewis rats. Thus. PPI in Lewis rats is relatively unaffected by either a pharmacological or a developmental manipulation, both of which disrupt PPI in Sprague-Dawley and Fischer F344 rats.

引用

页码：1450 / 1457

页数：8

共 43 条

[1] Comparison of the behavioural and endocrine response to forced swimming stress in five inbred strains of rats [J].

Armario, A ;

Gavalda, A ;

Marti, J .

PSYCHONEUROENDOCRINOLOGY, 1995, 20 (08) :879-890

[2] Reversal of isolation rearing-induced deficits in prepulse inhibition by seroquel and olanzapine [J].

Bakshi, VP ;

Swerdlow, NR ;

Braff, DL ;

Geyer, MA .

BIOLOGICAL PSYCHIATRY, 1998, 43 (06) :436-445

[3] ANTAGONISM OF PHENCYCLIDINE-INDUCED DEFICITS IN PREPULSE INHIBITION BY THE PUTATIVE ATYPICAL ANTIPSYCHOTIC OLANZAPINE [J].

BAKSHI, VP ;

GEYER, MA .

PSYCHOPHARMACOLOGY, 1995, 122 (02) :198-201

[4]

BAKSHI VP, 1994, J PHARMACOL EXP THER, V271, P787

[5] STARTLE REFLEX HABITUATION IN FUNCTIONAL PSYCHOSES - A CONTROLLED-STUDY [J].

BOLINO, F ;

MANNA, V ;

DICICCO, L ;

DIMICHELE, V ;

DANELUZZO, E ;

ROSSI, A ;

CASACCHIA, M .

NEUROSCIENCE LETTERS, 1992, 145 (02) :126-128

[6] PRE-STIMULUS EFFECTS ON HUMAN STARTLE REFLEX IN NORMALS AND SCHIZOPHRENICS [J].

BRAFF, D ;

STONE, C ;

CALLAWAY, E ;

GEYER, M ;

GLICK, I ;

BALI, L .

PSYCHOPHYSIOLOGY, 1978, 15 (04) :339-343

[7]

BRAFF DL, 1992, ARCH GEN PSYCHIAT, V49, P206

[8] THE GLYCINE NMDA RECEPTOR ANTAGONIST, L-701,324 REVERSES ISOLATION-INDUCED DEFICITS IN PREPULSE INHIBITION IN THE RAT [J].

BRISTOW, LJ ;

LANDON, L ;

SAYWELL, KL ;

TRICKLEBANK, MD .

PSYCHOPHARMACOLOGY, 1995, 118 (02) :230-232

[9] THE EFFECTS OF METHAMPHETAMINE AND COCAINE ON MOTOR BEHAVIOR AND EXTRACELLULAR DOPAMINE IN THE VENTRAL STRIATUM OF LEWIS VERSUS FISCHER-344 RATS [J].

CAMP, DM ;

BROWMAN, KE ;

ROBINSON, TE .

BRAIN RESEARCH, 1994, 668 (1-2) :180-193

[10] MALE FISCHER-344 AND LEWIS RATS DISPLAY DIFFERENCES IN LOCOMOTOR REACTIVITY, BUT NOT IN ANXIETY-RELATED BEHAVIORS - RELATIONSHIP WITH THE HIPPOCAMPAL SEROTONERGIC SYSTEM [J].

CHAOULOFF, F ;

KULIKOV, A ;

SARRIEAU, A ;

CASTANON, N ;

MORMEDE, P .

BRAIN RESEARCH, 1995, 693 (1-2) :169-178

← 1 2 3 4 5 →