Drug-cyclodextrin association constants determined by surface tension and surface pressure measurements -: I.: Host-guest complexation of water soluble drugs by cyclodextrins:: Polymyxin B-β cyclodextrin system

被引：48

作者：

Angelova, A ^{[1
]}

Ringard-Lefebvre, C ^{[1
]}

Baszkin, A ^{[1
]}

机构：

[1] Univ Paris Sud, Ctr Etud Pharmaceut, CNRS, URA 1218, F-92296 Chatenay Malabry, France

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 1999年 / 212卷 / 02期

关键词：

inclusion complexes; binding constants; cyclodextrins; polymyxin B; surface tension; drug sequestration;

D O I：

10.1006/jcis.1999.6088

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The complexation reaction between the amphiphilic peptide antibiotic polymyxin B and naturally occurring cyclodextrins, used as potential drug carriers, was quantitatively evaluated from surface tension measurements at various drug concentrations, The association constant, K-a, of polymyxin B:beta-cyclodextrin inclusion complex formation of 1:1 stoichiometry was determined from the change in the drug interfacial activity upon the addition of beta-cyclodextrin at the excess solution concentration (10(-3) M). The obtained K-a value is discussed in terms of molecular matching of the host cyclodextrin cavity and the guest drug molecule. (C) 1999 Academic Press.

引用

页码：275 / 279

页数：5

共 18 条

[1] The effect of ternary complex formation on the partitioning of pyrene and anthracene in aqueous solutions containing sodium dodecyl sulfate and M-gamma-cyclodextrin [J].