Sensing of cadmium and copper ions by externally exposed ADL, ASE, and ASH neurons elicits avoidance response in Caenorhabditis elegans

被引：116

作者：

Sambongi, Y ^{[1
]}

Nagae, T ^{[1
]}

Liu, Y ^{[1
]}

Yoshimizu, T ^{[1
]}

Takeda, K ^{[1
]}

Wada, Y ^{[1
]}

Futai, M ^{[1
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, Div Biol Sci, Japan Sci & Technol Corp,CREST, Osaka 5670047, Japan

来源：

NEUROREPORT | 1999年 / 10卷 / 04期

关键词：

avoidance behavior; Caenorhabditis elegans; chemosensory neurons; heavy metal ions; laser microsurgery;

D O I：

10.1097/00001756-199903170-00017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE developed a quantitative assay for Caenorhabditis elegans avoidance behavior. This was then used to demonstrate that the worm moved away from toxic concentrations of Cd2+ and Cu2+, but not Ni2+, all ions that prevented development from larval to adult stages. Mutants that have structural defects in ciliated neurons (che-2 and osm-3) as well as worms with three laser-operated neurons (ADL, ASE, and ASH), showed no avoidance behavior from Cd2+ and Cu2+. These results suggest that the avoidance from Cd2+ and Cu2+ are mediated through multiple neural pathways including ADL, ASE, and ASH neurons. We hypothesize that the three sensing neurons provide increased accuracy of the sensory response and a survival advantage in the natural environment of the worm. NeuroReport 10:753-757 (C) 1999 Lippincott Williams & Wilkins.

引用

页码：753 / 757

页数：5

共 22 条

[1] CHEMOSENSORY NEURONS WITH OVERLAPPING FUNCTIONS DIRECT CHEMOTAXIS TO MULTIPLE CHEMICALS IN C-ELEGANS [J].