HIV-1 Neutralization Coverage Is Improved by Combining Monoclonal Antibodies That Target Independent Epitopes

被引：65

作者：

Doria-Rose, Nicole A. ^{[1
]}

Louder, Mark K. ^{[1
]}

Yang, Zhongjia ^{[1
]}

O'Dell, Sijy ^{[1
]}

Nason, Martha ^{[1
]}

Schmidt, Stephen D. ^{[1
]}

McKee, Krisha ^{[1
]}

Seaman, Michael S. ^{[2
]}

Bailer, Robert T. ^{[1
]}

Mascola, John R. ^{[1
]}

机构：

[1] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Med, Div Viral Pathogenesis,Med Sch, Boston, MA 02215 USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 06期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; ENV CLONES; CD4; BINDING; POTENT; BROAD; TRANSMISSION; INFECTION; PROTECTION; IMMUNIZATION; PREVENTION;

D O I：

10.1128/JVI.06745-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV-1 neutralizing monoclonal antibodies (MAbs) define key targets for vaccine development and are being considered for passive prevention of infection. We analyzed the interaction of MAbs to two independent epitopes on the viral envelope glycoprotein. Potently neutralizing MAbs to the CD4 binding site and V1V2 region displayed no in vitro cross-competition and displayed additive, though not synergistic, neutralization activity. Predicted neutralization coverage of a combination of two MAbs reached 97% on a 208-isolate panel.

引用

页码：3393 / 3397

页数：5

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