Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking

被引：253

作者：

Sigmundsdottir, Hekla

Butcher, Eugene C. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

来源：

NATURE IMMUNOLOGY | 2008年 / 9卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/ni.f.208

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymphocytes are imprinted during activation with trafficking programs (combinations of adhesion and chemoattractant receptors) that target their migration to specific tissues and microenvironments. Cytokines contribute, but, for gut and skin, evolution has cleverly adapted external cues from food (vitamin A) and sunlight (ultraviolet-induced vitamin D3) to imprint lymphocyte homing to the small intestines and T cell migration into the epidermis. Dendritic cells are essential: they process the vitamins to their active metabolites (retinoic acid and 1,25(OH)(2)D3) for presentation with antigen to lymphocytes, and they help export environmental cues through lymphatics to draining lymph nodes, to program the trafficking and effector functions of naive T and B cells.

引用

页码：981 / 987

页数：7

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