Skeletal deformities induced by the intraperitoneal administration of deoxynivalenol (vomitoxin) in mice

被引：37

作者：

Debouck, C ^{[1
]}

Haubruge, E ^{[1
]}

Bollaerts, P ^{[1
]}

van Bignoot, D ^{[1
]}

Brostaux, Y ^{[1
]}

Werry, A ^{[1
]}

Rooze, M ^{[1
]}

机构：

[1] Univ Brussels, Dept Anat & Embryol, Brussels, Belgium

来源：

INTERNATIONAL ORTHOPAEDICS | 2001年 / 25卷 / 03期

关键词：

D O I：

10.1007/s002640100235

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The contamination of drinking water by organic acids, selenium deficiency and the ingestion of fungal mycotoxins are the three main aetiological factors in the development of Kashin-Beck disease. An avian tibial chondrodysplasia induced by mycotoxins has been reported. Deoxynivalenol (DON) is one of many mycotoxins produced by the most common contaminating species of fungi. The pattern of skeletal malformations induced by its administration intraperitoneally to pregnant mice is reported. Costo-vertebral segmentation abnormalities were the main deformities observed. The chondrodysplasia previously described was not seen.

引用

页码：194 / 198

页数：5

共 15 条

[1]

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