A propensity score-matched cohort study of the effect of statins, mainly, Fluvastatin, on the occurrence of acute myocardial infarction

被引:44
作者
Seeger, JD
Walker, AM
Williams, PL
Saperia, GM
Sacks, FM
机构
[1] Ingenix Epidemiol, Riverside Ctr, Auburndale, MA 02466 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
[4] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
[5] Fallon Clin Inc, Dept Cardiol, Worcester, MA USA
关键词
D O I
10.1016/j.amjcard.2003.08.057
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This investigation quantified the effect of statins on acute myocardial infarction (AMI) in an observational setting where fluvastatin represented most of the statin use. The study applied propensity scores to match statin initiators to statin noninitiators and followed them for the occurrence of AMI. Serum low-density lipoprotein levels were reduced by statin therapy, and there were fewer incidents of AMI in statin initiators than in noninitiators. (C) 2003 by Excerpta Medica, Inc.
引用
收藏
页码:1447 / 1451
页数:5
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