Hyperinsulinemia in African-American adolescents compared with their American white peers despite similar insulin sensitivity -: A reflection of upregulated β-cell function?

被引:55
作者
Hannon, Tamara S. [1 ]
Bacha, Fida [1 ]
Lin, Yan [2 ]
Arslanian, Silva A. [1 ]
机构
[1] Childrens Hosp Pittsburgh, Div Pediatr Endocrinol Metab & Diabet, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Ctr Res Hlth Care, Pittsfield, MA USA
关键词
D O I
10.2337/dc08-0116
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE - African-American (AA) children are hyperinsulinemic and insulin resistant compared with American white (AW) children. Previously, we demonstrated that insulin secretion relative to insulin sensitivity was similar to 75% higher in AA compared with AW children, suggesting that hyperinsulinemia in AA children is not merely a compensatory response to lower insulin sensitivity. The aim of the present investigation was to assess whether glucose-stimulated insulin response is higher in AA versus AW adolescents who have comparable in vivo insulin sensitivity. RESEARCH DESIGN AND METHODS - The hyperinsulinemic-euglycemic and hyperglycemic clamp techniques were utilized to assess first- and second-phase insulin secretion. Insulin secretion relative to insulin sensitivity was calculated as the glucose disposition index. RESULTS - AA adolescents compared with their AW peers with comparable insulin sensitivity and body composition had higher first-phase insulin concentrations. CONCLUSIONS - The quantitative relationship between insulin sensitivity and first-phase insulin appears to differ among AA and AW adolescents.
引用
收藏
页码:1445 / 1447
页数:3
相关论文
共 8 条
[1]   Hyperinsulinemia in African-American children - Decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivity [J].
Arslanian, SA ;
Saad, H ;
Lewy, V ;
Danadian, K ;
Janosky, J .
DIABETES, 2002, 51 (10) :3014-3019
[2]   Comparison of measured and estimated indices of insulin sensitivity and β cell function:: Impact of ethnicity on insulin sensitivity and β cell function in glucose-tolerant and normotensive subjects [J].
Chiu, KC ;
Chuang, LM ;
Yoon, C .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (04) :1620-1625
[3]   Insulin sensitivity in African-American children with and without family history of type 2 diabetes [J].
Danadian, K ;
Balasekaran, G ;
Lewy, V ;
Meza, MP ;
Robertson, R ;
Arslanian, SA .
DIABETES CARE, 1999, 22 (08) :1325-1329
[4]  
DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
[5]   Visceral fat, insulin sensitivity, and lipids in prepubertal children [J].
Gower, BA ;
Nagy, TR ;
Goran, MI .
DIABETES, 1999, 48 (08) :1515-1521
[6]   Using genetic admixture to explain racial differences in insulin-related phenotypes [J].
Gower, BA ;
Fernández, JR ;
Beasley, TM ;
Shriver, MD ;
Goran, MI .
DIABETES, 2003, 52 (04) :1047-1051
[7]   Insulin resistance - Link to the components of the metabolic syndrome and biomarkers of endothelial dysfunction in youth [J].
Lee, SoJung ;
Gungor, Neslihan ;
Bacha, Fida ;
Arslanian, Silva .
DIABETES CARE, 2007, 30 (08) :2091-2097
[8]   BLACK-WHITE CONTRASTS IN INSULIN LEVELS DURING PUBERTAL DEVELOPMENT - THE BOGALUSA HEART-STUDY [J].
SVEC, F ;
NASTASI, K ;
HILTON, C ;
BAO, WH ;
SRINIVASAN, SR ;
BERENSON, GS .
DIABETES, 1992, 41 (03) :313-317