Determining Biomembrane Bending Rigidities from Simulations of Modest Size

被引：108

作者：

Watson, Max C. ^{[1
]}

Brandt, Erik G. ^{[2
,3
]}

Welch, Paul M. ^{[4
]}

Brown, Frank L. H. ^{[1
,3
]}

机构：

[1] Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA

[2] Univ Calif Santa Barbara, Dept Math, Santa Barbara, CA 93106 USA

[3] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

[4] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA

来源：

PHYSICAL REVIEW LETTERS | 2012年 / 109卷 / 02期

基金：

美国国家科学基金会;

关键词：

MOLECULAR-DYNAMICS SIMULATIONS; COARSE-GRAINED MODEL; RED-BLOOD-CELL; LIPID-BILAYERS; ELASTIC PROPERTIES; LIQUID-CRYSTALS; MEMBRANE; VESICLES; ENERGY; UNDULATIONS;

D O I：

10.1103/PhysRevLett.109.028102

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Thermal fluctuations of lipid orientation are analyzed to infer the bending rigidity of lipid bilayers directly from molecular simulations. Compared to the traditional analysis of thermal membrane undulations, the proposed method is reliable down to shorter wavelengths and allows for determination of the bending rigidity using smaller simulation boxes. The requisite theoretical arguments behind this analysis are presented and verified by simulations spanning a diverse range of lipid models from the literature.

引用

页数：5

共 40 条

[1] Membrane elasticity in giant vesicles with fluid phase coexistence [J].

Baumgart, T ;

Das, S ;

Webb, WW ;

Jenkins, JT .

BIOPHYSICAL JOURNAL, 2005, 89 (02) :1067-1080

[2] Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperature [J].

Berger, O ;

Edholm, O ;

Jahnig, F .

BIOPHYSICAL JOURNAL, 1997, 72 (05) :2002-2013

[3] DETERMINATION OF BILAYER-MEMBRANE BENDING STIFFNESS BY TETHER FORMATION FROM GIANT, THIN-WALLED VESICLES [J].

BO, L ;

WAUGH, RE .

BIOPHYSICAL JOURNAL, 1989, 55 (03) :509-517

[4]

BOAL D, 2002, MECH CELL

[5]

BRANDT EN, IN PRESS

[6] Interpretation of Fluctuation Spectra in Lipid Bilayer Simulations [J].

Brandt, Erik G. ;

Braun, Anthony R. ;

Sachs, Jonathan N. ;

Nagle, John F. ;

Edholm, Olle .

BIOPHYSICAL JOURNAL, 2011, 100 (09) :2104-2111

[7] Flexible lipid bilayers in implicit solvent [J].

Brannigan, G ;

Philips, PF ;

Brown, FLH .

PHYSICAL REVIEW E, 2005, 72 (01)

[8] Elastic deformation of membrane bilayers probed by deuterium NMR relaxation [J].

Brown, MF ;

Thurmond, RL ;

Dodd, SW ;

Otten, D ;

Beyer, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (28) :8471-8484

[9] MINIMUM ENERGY OF BENDING AS A POSSIBLE EXPLANATION OF BICONCAVE SHAPE OF HUMAN RED BLOOD CELL [J].

CANHAM, PB .

JOURNAL OF THEORETICAL BIOLOGY, 1970, 26 (01) :61-&

[10]

CHERNOMORDIK L, 1995, J MEMBRANE BIOL, V146, P1

← 1 2 3 4 →