RINGs hold the key to ubiquitin transfer

被引:154
作者
Budhidarmo, Rhesa [1 ]
Nakatani, Yoshio [1 ]
Day, Catherine L. [1 ]
机构
[1] Univ Otago, Dept Biochem, Dunedin 9054, New Zealand
关键词
U-BOX; CONJUGATING ENZYME; CRYSTAL-STRUCTURE; ALLOSTERIC ACTIVATION; MECHANISTIC INSIGHT; ANTAGONISTS INDUCE; LIGASE CHIP; COMPLEX; UBIQUITYLATION; REVEALS;
D O I
10.1016/j.tibs.2011.11.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ubiquitylation, the covalent modification of proteins by the addition of ubiquitin, relies on a cascade of enzymes that culminates in an E3 ligase that promotes the transfer of ubiquitin from an E2 enzyme to the target protein. The most prevalent E3 ligases contain a type of zinc-finger domain called RING, and although an essential role for the RING domain in ubiquitin transfer is widely accepted, the molecular mechanism by which this is achieved remains uncertain. In this review, we highlight recent studies that have suggested that the RING domain modulates the stability of the E2 similar to ubiquitin conjugate so that catalysis is promoted. We also review the role of RING dimerisation and emphasise the importance of studying RING domains in the context of the full-length protein.
引用
收藏
页码:58 / 65
页数:8
相关论文
共 59 条
[1]   Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI [J].
Alpi, Arno F. ;
Pace, Paul E. ;
Babu, M. Madan ;
Patel, Ketan J. .
MOLECULAR CELL, 2008, 32 (06) :767-777
[2]   Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2 [J].
Alvarez, Sergio E. ;
Harikumar, Kuzhuvelil B. ;
Hait, Nitai C. ;
Allegood, Jeremy ;
Strub, Graham M. ;
Kim, Eugene Y. ;
Maceyka, Michael ;
Jiang, Hualiang ;
Luo, Cheng ;
Kordula, Tomasz ;
Milstien, Sheldon ;
Spiegel, Sarah .
NATURE, 2010, 465 (7301) :1084-U149
[3]   Structure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease [J].
Beasley, Steven A. ;
Hristova, Ventzislava A. ;
Shaw, Gary S. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (09) :3095-3100
[4]   Constructing and decoding unconventional ubiquitin chains [J].
Behrends, Christian ;
Harper, J. Wade .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 18 (05) :520-528
[5]   Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4 [J].
Benirschke, Robert C. ;
Thompson, James R. ;
Nomine, Yves ;
Wasielewski, Emeric ;
Juranic, Nenad ;
Macura, Slobodan ;
Hatakeyama, Shigetsugu ;
Nakayama, Keiichi I. ;
Botuyan, Maria Victoria ;
Mer, Georges .
STRUCTURE, 2010, 18 (08) :955-965
[6]   Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex [J].
Bentley, Matthew L. ;
Corn, Jacob E. ;
Dong, Ken C. ;
Phung, Qui ;
Cheung, Tommy K. ;
Cochran, Andrea G. .
EMBO JOURNAL, 2011, 30 (16) :3285-3297
[7]   Binding and recognition in the assembly of an active BRCA1 /BARD1 ubiquitin-ligase complex [J].
Brzovic, PS ;
Keeffe, JR ;
Nishikawa, H ;
Miyamoto, K ;
Fox, D ;
Fukuda, M ;
Ohta, T ;
Klevit, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (10) :5646-5651
[8]   A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination [J].
Brzovic, PS ;
Lissounov, A ;
Christensen, DE ;
Hoyt, DW ;
Klevit, RE .
MOLECULAR CELL, 2006, 21 (06) :873-880
[9]   Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b [J].
Buchwald, Gretel ;
van der Stoop, Petra ;
Weichenrieder, Oliver ;
Perrakis, Anastassis ;
van Lohuizen, Maarten ;
Sixma, Titia K. .
EMBO JOURNAL, 2006, 25 (11) :2465-2474
[10]   Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING [J].
Capili, AD ;
Edghill, EL ;
Wu, K ;
Borden, KLB .
JOURNAL OF MOLECULAR BIOLOGY, 2004, 340 (05) :1117-1129