The chemistry of 2-aminocycloalkanecarboxylic acids

被引：356

作者：

Fülöp, F ^{[1
]}

机构：

[1] Univ Szeged, Inst Pharmaceut Chem, H-6701 Szeged, Hungary

来源：

CHEMICAL REVIEWS | 2001年 / 101卷 / 07期

关键词：

D O I：

10.1021/cr000456z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis and transformations of 2-aminocycloalkanecarboxylic acids were discussed. The resolution of the racemates by diastereomer separation and biocatalyzed transformations were studied. It was found that the selective reductive aminations of β-ketoesters via enamines resulted into the accurate ratios of cis and trans diastereomers. The synthesis of 2-aminocycloalkanecarboxylic acids from 1,2-dicarboxylic acids derivatives by rearrangements was also elaborated.

引用

页码：2181 / 2204

页数：24

共 441 条

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