Neuronal diversity and temporal dynamics: The unity of hippocampal circuit operations

被引：1503

作者：

Klausberger, Thomas ^{[1
,2
]}

Somogyi, Peter ^{[1
]}

机构：

[1] Univ Oxford, MRC, Anat Neuropharmacol Unit, Oxford OX1 3TH, England

[2] Med Univ Vienna, Ctr Brain Res, A-1090 Vienna, Austria

来源：

SCIENCE | 2008年 / 321卷 / 5885期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1126/science.1149381

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the cerebral cortex, diverse types of neurons form intricate circuits and cooperate in time for the processing and storage of information. Recent advances reveal a spatiotemporal division of labor in cortical circuits, as exemplified in the CA1 hippocampal area. In particular, distinct GABAergic (gamma- aminobutyric acid- releasing) cell types subdivide the surface of pyramidal cells and act in discrete time windows, either on the same or on different subcellular compartments. They also interact with glutamatergic pyramidal cell inputs in a domain- specific manner and support synaptic temporal dynamics, network oscillations, selection of cell assemblies, and the implementation of brain states. The spatiotemporal specializations in cortical circuits reveal that cellular diversity and temporal dynamics coemerged during evolution, providing a basis for cognitive behavior.

引用

页码：53 / 57

页数：5

共 68 条

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