Complications associated with new-onset diabetes after kidney transplantation

被引:63
作者
Sharif, Adnan [1 ]
Baboolal, Keshwar [2 ]
机构
[1] Queen Elizabeth Hosp, Dept Nephrol & Transplantat, Renal Inst Birmingham, Birmingham B15 2TH, W Midlands, England
[2] Univ Wales Hosp, Dept Nephrol, Cardiff CF14 4XW, S Glam, Wales
关键词
QUALITY-OF-LIFE; RISK-FACTORS; RENAL-TRANSPLANTATION; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; ACUTE REJECTION; PLASMA-GLUCOSE; GRAFT FUNCTION; MELLITUS;
D O I
10.1038/nrneph.2011.174
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
New-onset diabetes mellitus after kidney transplantation (NODAT) is widely acknowledged to be associated with increased morbidity and mortality, as well as poor quality of life. Clear evidence links the occurrence of NODAT to accelerated progression of some macrovascular and/or microvascular complications. However, the evidence that some complications commonly attributed to diabetes mellitus occur in the context of transplantation lacks robustness. Certain complications are transplantation-specific and prevalent, but others are not frequently observed or documented. For this reason, it is essential that clinicians are aware of the array of potential complications associated with NODAT in kidney allograft recipients. Rather than simply translating evidence from the general population to the high-risk transplant recipient, this Review aims to provide specific guidance on diabetes-related complications in the context of a complex transplantation environment.
引用
收藏
页码:34 / 42
页数:9
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