Male predominance among Japanese adult patients with late-onset hemorrhagic cystitis after hematopoietic stem cell transplantation

被引：38

作者：

Asano, Y ^{[1
]}

Kanda, Y ^{[1
]}

Ogawa, N ^{[1
]}

Sakata-Yanagimoto, M ^{[1
]}

Nakagawa, M ^{[1
]}

Kawazu, M ^{[1
]}

Goyama, S ^{[1
]}

Kandabashi, K ^{[1
]}

Izutsu, K ^{[1
]}

Imai, Y ^{[1
]}

Hangaishi, A ^{[1
]}

Kurokawa, M ^{[1
]}

Tsujino, S ^{[1
]}

Ogawa, S ^{[1
]}

Aoki, K ^{[1
]}

Chiba, S ^{[1
]}

Motokura, T ^{[1
]}

Hirai, H ^{[1
]}

机构：

[1] Tokyo Univ Hosp, Dept Cell Therapy & Transplantat Med, Tokyo 113, Japan

来源：

BONE MARROW TRANSPLANTATION | 2003年 / 32卷 / 12期

关键词：

hemorrhagic cystitis; adenovirus; hematopoietic stem cell transplantation;

D O I：

10.1038/sj.bmt.1704274

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Late-onset hemorrhagic cystitis (LHC) after hematopoietic stem cell transplantation (HSCT) is mainly caused by viral infections. We retrospectively analyzed the records of 141 Japanese adult patients who underwent a first allogeneic HSCT from 1995 to 2002. In all, 19 patients developed LHC a median of 51 days after HSCT. Adenovirus (AdV) was detected in the urine of 10 LHC patients, of whom eight had AdV type 11. Five of the six available serum samples from these patients were also positive for AdV type 11, but the detection of AdV in serum was not associated with a worse outcome. Male sex and the development of grade II-IV acute graft-versus-host disease were identified as independent significant risk factors for LHC. Male predominance was detected in LHC after HSCT, as has been previously shown in children with AdV-induced acute HC. The detection of AdV DNA in serum did not predict a poor outcome.

引用

页码：1175 / 1179

页数：5

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