PAF and haematopoiesis .4. Platelet-activating factor increases DNA synthesis in human bone marrow cells

被引：13

作者：

Denizot, Y

Dupuis, F

Trimoreau, F

Verger, C

Allegraud, A

Praloran, V

机构：

[1] Lab. d'Hematologie Experimentale, Faculté de Médecine, 87025 Limoges

来源：

JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING | 1996年 / 15卷 / 01期

关键词：

PAF; bone marrow cells; thymidine incorporation; haematopoiesis; human;

D O I：

10.1016/S0929-7855(96)00447-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Platelet-activating factor (PAF) is present in human bone marrow leading us to investigate its effect on human bone marrow cell proliferation. While PAF (0.1 mu M to 1 nM) stimulates the incorporation of [H-3]thymidine by freshly isolated adherent human bone marrow cells, PAF has no effect on non adherent cells. A non-metabolizable PAF agonist is more potent than PAF to stimulate thymidine incorporation in adherent cells. The precise role of PAF in human haematopoiesis in vivo remains to be clarified.

引用

页码：1 / 4

页数：4

共 8 条

[1] PAF AND HEMATOPOIESIS .3. PRESENCE AND METABOLISM OF PLATELET-ACTIVATING-FACTOR IN HUMAN BONE-MARROW [J].