NOD-like receptors: Ancient sentinels of the innate immune system

被引：49

作者：

Rosenstiel, P. ^{[1
]}

Jacobs, G. ^{[1
]}

Till, A. ^{[1
]}

Schreiber, S. ^{[1
,2
]}

机构：

[1] Univ Hosp Schleswig Holstein Campus Keil, Inst Clin Mol Biol, Dept Cell Biol & Marine Med, D-24105 Kiel, Germany

[2] Univ Hosp Schleswig Holstein Campus Keil, Dept Med 1, D-24105 Kiel, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 09期

关键词：

innate immunity; Crohn disease; epithelial barrier; inflammation; NF-kappa B; caspases;

D O I：

10.1007/s00018-008-7502-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NOD-like receptors (NLRs) comprise a family of cytosolic proteins that have been implicated as ancient cellular sentinels mediating protective immune responses elicited by intracellular pathogens or endogenous danger signals. Genetic variants in NLR genes have been associated with complex chronic inflammatory barrier diseases (e.g. Crohn disease, bronchial asthma). In this review, we focus on the molecular pathophysiology of NLRs in the context of chronic inflammatory diseases and pinpoint recent advances in the evolutionary understanding of NLR biology. We propose that the field of NLRs may serve as a prototype for how a comprehensive understanding of an element of the immunological barrier will eventually lead to the development of targeted diagnostic, therapeutic and/or preventive strategies.

引用

收藏

页码：1361 / 1377

页数：17

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