Sodium-dependent glucose transporter protein as a potential therapeutic target for improving glycemic control in diabetes

被引：9

作者：

Castaneda-Sceppa, Carmen ^{[2
]}

Castaneda, Francisco ^{[1
]}

机构：

[1] Klin Herzberg, D-37412 Herzberg Am Harz, Germany

[2] Northeastern Univ, Bouve Coll Hlth Sci, Boston, MA 02115 USA

来源：

NUTRITION REVIEWS | 2011年 / 69卷 / 12期

关键词：

diabetes treatment; diabetes-related complications; hyperglycemia; sodium-glucose transport proteins; RANDOMIZED CONTROLLED-TRIAL; SELECTIVE SGLT2 INHIBITOR; SKELETAL-MUSCLE; INSULIN-RESISTANCE; VITAMIN-D; PHARMACOLOGICAL-PROPERTIES; COTRANSPORTER INHIBITORS; ANTIDIABETIC AGENTS; SIGNAL-TRANSDUCTION; PHYSICAL-ACTIVITY;

D O I：

10.1111/j.1753-4887.2011.00423.x

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Glucose is transported across the cell membrane by two different types of glucose transporters: glucose-facilitated transporters and sodium-dependent glucose transport (SGLT) proteins. Regulation of SGLT activity (namely, inhibition of SGLT1 and SGLT2 activity and stimulation of SGLT3 activity) represents a potential means of managing hyperglycemia and diabetes, thus preventing complications of diabetes. The purpose of the present review is to discuss the role of SGLT proteins in the pathophysiology of diabetes and to describe the mechanisms by which these transporters may be used for glycemic control and the treatment of diabetes. The regulatory processes involved in SGLT-mediated glucose uptake are also described briefly. This information provides new insight into the complementary mechanisms involved in the regulation of SGLT-mediated glucose transport as well as a basis for further investigation. (C) 2011 International Life Sciences Institute

引用

页码：720 / 729

页数：10

共 127 条

[11] Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in Type 2 diabetes mellitus [J].

Boulé, NG ;

Kenny, GP ;

Haddad, E ;

Wells, GA ;

Sigal, RJ .

DIABETOLOGIA, 2003, 46 (08) :1071-1081

[12] Dapagliflozin for the Treatment of Type 2 Diabetes [J].

Brooks, Arnie McCord ;

Thacker, Stacey M. .

ANNALS OF PHARMACOTHERAPY, 2009, 43 (7-8) :1286-1293

[13]

Brooks Naomi, 2006, Int J Med Sci, V4, P19

[14] Glucose transporters in diabetic nephropathy [J].

Brosius, FC ;

Heilig, CW .

PEDIATRIC NEPHROLOGY, 2005, 20 (04) :447-451

[15] Biochemistry and molecular cell biology of diabetic complications [J].

Brownlee, M .

NATURE, 2001, 414 (6865) :813-820

[16] Regulated transport of the glucose transporter glut4 [J].

Bryant, NJ ;

Govers, R ;

James, DE .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (04) :267-277

[17] The Role of Physical Activity in Type 2 Diabetes Prevention: Physiological and Practical Perspectives [J].

Burr, Jamie F. ;

Rowan, Chip P. ;

Jamnik, Veronica K. ;

Riddell, Michael C. .

PHYSICIAN AND SPORTSMEDICINE, 2010, 38 (01) :72-82

[18]

Calado J, 2009, IDRUGS, V12, P785

[19] Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion [J].

Calado, Joaquim ;

Sznajer, Yves ;

Metzger, Daniel ;

Rita, Ana ;

Hogan, Marie C. ;

Kattamis, Antonis ;

Scharf, Mauro ;

Tasic, Velibor ;

Greil, Johann ;

Brinkert, Florian ;

Kemper, Markus J. ;

Santer, Rene .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2008, 23 (12) :3874-3879

[20] Genomic actions of 1,25-dihydroxyvitamin D3 on insulin receptor gene expression, insulin receptor number and insulin activity in the kidney, liver and adipose tissue of streptozotocin-induced diabetic rats [J].

Calle, Consuelo ;

Maestro, Begona ;

Garcia-Arencibia, Moises .

BMC MOLECULAR BIOLOGY, 2008, 9

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