Impaired detection of variable duration embedded tones in ectopic NZB/BINJ mice

被引:31
作者
Peiffer, AM
Dunleavy, CK
Frenkel, M
Gabel, LA
LoTurco, JJ
Rosen, GD
Fitch, RH
机构
[1] Univ Connecticut, Dept Psychol, Behav Neurosci Div, Storrs, CT 06269 USA
[2] Univ Connecticut, Dept Physiol & Neurobiol, Storrs, CT 06269 USA
[3] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol, Cambridge, MA 02138 USA
关键词
auditory discrimination; auditory event-related potentials; cortex; dyslexia; language impairments; phonological deficits; reflex modification;
D O I
10.1097/00001756-200109170-00024
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Utilizing rodent models, prior research has demonstrated a significant association between focal neocortical malformations (i.e. induced microgyria, molecular layer ectopias), which are histologically similar to those observed in human dyslexic brains, and rate-specific auditory processing deficits as seen in language impaired populations. In the current study, we found that ectopic NZB/BINJ mice exhibit significant impairments in detecting a variable duration 5.6 kHz tone embedded in a 10.5 kHz continuous background, using both acoustic reflex modification and auditory event-related potentials (AERP). The current results add further support to the association between focal cortical malformations and impaired auditory processing, and the notion that these auditory effects may occur regardless of the cortical location of the anomaly. NeuroReport 12:2875-2879 (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码:2875 / 2879
页数:5
相关论文
共 20 条
[1]   Perceptual auditory gap detection deficits in male BXSB mice with cerebrocortical ectopias [J].
Clark, MG ;
Sherman, GF ;
Bimonte, HA ;
Fitch, RH .
NEUROREPORT, 2000, 11 (04) :693-696
[2]  
CLARK MG, 2000, J COGN NEUROSCI, V12
[3]   The evidence for a temporal processing deficit linked to dyslexia: A Review [J].
Farmer, ME ;
Klein, RM .
PSYCHONOMIC BULLETIN & REVIEW, 1995, 2 (04) :460-493
[4]   Effects of sex and MK-801 on auditory-processing deficits associated with developmental microgyric lesions in rats [J].
Fitch, RH ;
Brown, CP ;
Tallal, P ;
Rosen, GD .
BEHAVIORAL NEUROSCIENCE, 1997, 111 (02) :404-412
[5]   INDUCED MICROGYRIA AND AUDITORY TEMPORAL PROCESSING IN RATS - A MODEL FOR LANGUAGE IMPAIRMENT [J].
FITCH, RH ;
TALLAL, P ;
BROWN, CP ;
GALABURDA, AM ;
ROSEN, GD .
CEREBRAL CORTEX, 1994, 4 (03) :260-270
[6]   Neocortical ectopias are associated with attenuated neurophysiological responses to rapidly changing auditory stimuli [J].
Frenkel, M ;
Sherman, GF ;
Bashán, KA ;
Galaburda, AM ;
LoTurco, JJ .
NEUROREPORT, 2000, 11 (03) :575-579
[7]   DEVELOPMENTAL DYSLEXIA - 4 CONSECUTIVE PATIENTS WITH CORTICAL ANOMALIES [J].
GALABURDA, AM ;
SHERMAN, GF ;
ROSEN, GD ;
ABOITIZ, F ;
GESCHWIND, N .
ANNALS OF NEUROLOGY, 1985, 18 (02) :222-233
[8]   EVIDENCE FOR ABERRANT AUDITORY ANATOMY IN DEVELOPMENTAL DYSLEXIA [J].
GALABURDA, AM ;
MENARD, MT ;
ROSEN, GD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (17) :8010-8013
[9]   PRENATAL REMOVAL OF FRONTAL ASSOCIATION CORTEX IN FETAL RHESUS-MONKEY - ANATOMICAL AND FUNCTIONAL CONSEQUENCES IN POSTNATAL LIFE [J].
GOLDMAN, PS ;
GALKIN, TW .
BRAIN RESEARCH, 1978, 152 (03) :451-485
[10]   Cerebral microgyria, thalamic cell size and auditory temporal processing in male and female rats [J].
Herman, AE ;
Galaburda, AM ;
Fitch, RH ;
Carter, AR ;
Rosen, GD .
CEREBRAL CORTEX, 1997, 7 (05) :453-464