mTOR Regulates T-Cell Differentiation and Activation in Immunity and Autoimmunity

被引：9

作者：

Bi, Yujing ^{[1
]}

Liu, Guangwei ^{[2
]}

Yang, Ruifu ^{[1
]}

机构：

[1] Acad Mil Med Sci, State Key Lab Pathogen & Biosecur, Army Ctr Microbial Detect & Res, Natl Ctr Biomed Anal,Inst Microbiol & Epidemiol, Beijing 100071, Peoples R China

[2] Chinese Acad Sci, Inst Zool, Beijing 100101, Peoples R China

来源：

CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION | 2011年 / 21卷 / 04期

基金：

中国国家自然科学基金;

关键词：

mTOR; T cell differentiation; immunity; autoimmunity; RIBOSOMAL-PROTEIN S6; MAMMALIAN TARGET; RAPAMYCIN; PHOSPHORYLATION; KINASE; EXPRESSION; PATHWAY; MEMORY; RECEPTOR; ANTIGEN;

D O I：

10.1615/CritRevEukarGeneExpr.v21.i4.20

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

mTOR is an evolutionarily conserved PI3-kinase family member that plays a central role in integrating environmental cues in the form of amino acids, energy, and growth factors. Recently, the kinase mTOR has emerged as an important regulator of the differentiation and function of helper T cells in immune responses and autoimmune diseases. In this review, we summarize the regulatory effects and mechanisms of mTOR complex in the differentiation of CD4(+) T and CD8(+) T cells. and T-cell homeostasis modulation. This should contribute to understanding the central role for mTOR in regulating immune responses and autoimmune diseases.

引用

收藏

页码：313 / 322

页数：10

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