Anion, cation, and zwitterion selectivity of phospholemman channel molecules

被引:44
作者
Kowdley, GC
Ackerman, SJ
Chen, ZH
Szabo, G
Jones, LR
Moorman, JR
机构
[1] UNIV VIRGINIA,HLTH SCI CTR,DEPT INTERNAL MED,DIV CARDIOL,CHARLOTTESVILLE,VA 22908
[2] UNIV VIRGINIA,HLTH SCI CTR,DEPT MOL PHYSIOL & BIOL PHYS,CHARLOTTESVILLE,VA 22908
[3] INDIANA UNIV,SCH MED,KRANNERT INST CARDIOL,DEPT INTERNAL MED,INDIANAPOLIS,IN 46202
关键词
D O I
10.1016/S0006-3495(97)78653-3
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Phospholemman (PLM), a 72-amino acid membrane protein with a single transmembrane domain, forms taurine-selective ion channels in lipid bilayers. Because taurine forms zwitterions, a taurine-selective channel might have binding sites for both anions and cations. Here we show that PLM channels indeed allow fluxes of both cations and anions, making instantaneous and voltage-dependent transitions among conformations with drastically different ion selectivity characteristics. This surprising and novel ion channel behavior offers a molecular explanation for selective taurine flux across cell membranes and may explain why molecules in the phospholemman family can induce cation- or anion-selective conductances when expressed in Xenopus oocytes.
引用
收藏
页码:141 / 145
页数:5
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